| Identification | More | [Name]
5-Chloro-2-methylaniline | [CAS]
95-79-4 | [Synonyms]
2-AMINO-4-CHLOROTOLUENE
3-CHLORO-6-METHYLANILINE
4-CHLORO-2-AMINO TOLUENE
4-CHLORO-2-TOLUIDINE
5-CHLORO-2-METHYLANILINE
5-CHLORO-O-TOLUIDINE
AKOS BBS-00003551
c.i. 37090
FAST RED KB BASE
LABOTEST-BB LTBB000735
PCOT
RED KB BASE
1-Amino-3-chloro-6-methylbenzene
1-amino-3-chloro-6-methylbenzene[qr]
2-amino-4-chlorotoluene[qr]
2-Methyl-5-chloroaniline
2-methyl-5-chloroaniline[qr]
3-chloro-6-methylaniline[qr]
4-chloro-2-aminotoluene[qr]
5-chloro-2-methylaniline[qr] | [EINECS(EC#)]
202-452-6 | [Molecular Formula]
C7H8ClN | [MDL Number]
MFCD00007779 | [Molecular Weight]
141.6 | [MOL File]
95-79-4.mol |
| Chemical Properties | Back Directory | [Appearance]
The chloromethylanilines are colorless or
white crystalline solids or liquids, some have a mild
fishy odor. | [Melting point ]
22 °C | [Boiling point ]
237 °C(lit.)
| [density ]
1.177 g/mL at 20 °C(lit.)
| [vapor pressure ]
0.45 hPa (50 °C) | [refractive index ]
n20/D 1.584(lit.)
| [Fp ]
320 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
soluble in Alcohol | [form ]
Liquid After Melting | [pka]
pK1:3.85(+1) (25°C) | [color ]
Clear yellow to light brown | [Water Solubility ]
< 1 g/L (22 ºC) | [BRN ]
878504 | [Henry's Law Constant]
6.3×100 mol/(m3Pa) at 25℃, HSDB (2015) | [InChI]
1S/C7H8ClN/c1-5-2-3-6(8)4-7(5)9/h2-4H,9H2,1H3 | [InChIKey]
WRZOMWDJOLIVQP-UHFFFAOYSA-N | [SMILES]
Clc1cc(c(cc1)C)N | [CAS DataBase Reference]
95-79-4(CAS DataBase Reference) | [IARC]
3 (Vol. 77, 99) 2010 | [NIST Chemistry Reference]
Benzenamine, 5-chloro-2-methyl-(95-79-4) | [EPA Substance Registry System]
95-79-4(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xn,T | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect.
R45:May cause cancer.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S53:Avoid exposure-obtain special instruction before use . | [RIDADR ]
UN 3429 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
XU5075000
| [Autoignition Temperature]
>540 °C | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214300 | [Storage Class]
6.1C - Combustible, acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | [Hazardous Substances Data]
95-79-4(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 464 mg/kg |
| Hazard Information | Back Directory | [Potential Exposure]
Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill
birds. It is marketed as pelleted bait for control of bird
populations. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
| [Shipping]
UN2239 Chlorotoluidines, solid, Hazard Class:
6.1; Labels: 6.1-Poisonous materials. UN3429
Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1-
Poisonous materials | [Incompatibilities]
Incompatible with oxidizers, strong
acids; chloroformates, and acid anhydrides, isocyanates,
aldehydes forming fire and explosive hazards. | [Chemical Properties]
clear yellow to light brown liquid after melting | [Chemical Properties]
The chloromethylanilines are colorless or
white crystalline solids or liquids, some have a mild
fishy odor. | [Uses]
5-Chloro-2-toluidine, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds including inhibitors. It is a carcinogenic monocyclic amine. The compound is used in synthesizing dyes. | [Definition]
ChEBI: 5-Chloro-ortho-toluidine is a member of monochlorobenzenes. | [Carcinogenicity]
A bioassay for the possible carcinogenicity of 5-chloro-otoluidine
was conducted using Fischer 344 rats and B6C3F1
mice. Groups of 50 male and 50 female rats and mice were
given 5-chloro-o-toluidine in the diet at 2500 or 5000 ppm for
rats and 2000 or 4000 ppm for mice. The compound was
administered for 78 weeks to both rats and mice, followed by
an observation period of up to 26 weeks for rats and 13 weeks
for mice. Under the conditions of this bioassay, 5-chloro-otoluidine
was carcinogenic to the mice, inducing hemangiosarcomas
and hepatocellular carcinomas in both males and
females. There was no conclusive evidence of the carcinogenicity
of the compound in the rats. | [References]
[1] Saim Top?u. “Synthesis, characterization and antioxidant activities of some novel oxime derivatives.” Pharmacy Pharmacology International Journal 25 1 (2021).
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