| Chemical Properties | Back Directory | [Boiling point ]
553.329±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.379±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
-0.217±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1]. | [in vivo]
SLC26A3-IN-2 (10 mg/kg; po) significantly increases stool weight and number of pellets in a Loperamide (HY-B0418A)-induced model of constipation in mice, demonstrating its efficacy in increasing stool hydration in mice[1]. | [References]
[1] Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149. DOI:10.1016/j.ejmech.2023.115149 |
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