| Identification | Back Directory | [Name]
glycyl-glycyl-cysteine | [CAS]
95416-30-1 | [Synonyms]
Gly-Gly-L-Cys
glycyl-glycyl-cysteine
L-Cysteine, glycylglycyl-
(2R)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-sulfanylpropanoic acid | [Molecular Formula]
C7H13N3O4S | [MDL Number]
MFCD00237921 | [MOL File]
95416-30-1.mol | [Molecular Weight]
235.26 |
| Hazard Information | Back Directory | [Uses]
Glycylglycylcysteine is a Thrombin Activatable Fibrinolysis Inhibitor (TAFI) inhibitor with a Ki of 0.99 μM and a IC50 of 9.4 μM in TAFI substrate assays. TAFI is a basic carboxypeptidase that functions as a fibrinolysis inhibitor through the cleavage of C-terminal lysine on partially degraded fibrin[1]. | [Definition]
ChEBI: Gly-Gly-Cys is an oligopeptide. | [References]
[1] Do YH, et al. Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives. Thromb Res. 2005;116(3):265-71. DOI:10.1016/j.thromres.2004.12.023 |
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