| Identification | Back Directory | [Name]
CH5015765 | [CAS]
959766-47-3 | [Synonyms]
CH5015765
4-(5-Chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-6-(methylthio)-1,3,5-triazin-2-amine
4-{7-chloro-3-oxatricyclo[7.3.1.05,13]trideca-1(13),5,7,9,11-pentaen-8-yl}-6-(methylsulfanyl)-1,3,5-triazin-2-amine | [Molecular Formula]
C16H13ClN4OS | [MDL Number]
MFCD28142703 | [MOL File]
959766-47-3.mol | [Molecular Weight]
344.82 |
| Chemical Properties | Back Directory | [Boiling point ]
668.7±65.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
2.61±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
CH5015765 is a novel, potent, and selective HSP90 inhibitor. CH5015765 showed high affinity for Hsp90 and antitumor activity in human cancer xenograft mouse models. | [Uses]
CH5015765 is an orally available Hsp90 inhibitor bound to the N-terminal ATP binding
site. CH5015765 plays an important role in cancer research[1]. | [IC 50]
HSP90 | [References]
[1] Atsushi Suda, et al. Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1136-41. DOI:10.1016/j.bmcl.2011.11.100 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Matrix Scientific
|
| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
|