| Identification | Back Directory | [Name]
LY 163443 | [CAS]
97581-70-9 | [Synonyms]
LY 163443
2'-Hydroxy-3'-propyl-4'-[4-[(1H-tetrazol-5-yl)methyl]phenoxymethyl]acetophenone
1-[2-Hydroxy-3-propyl-4-[[4-[(1H-tetrazol-5-yl)methyl]phenoxy]methyl]phenyl]ethanone | [Molecular Formula]
C20H22N4O3 | [MOL File]
97581-70-9.mol |
| Hazard Information | Back Directory | [Uses]
LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4[1][2]. | [References]
[1] Fleisch JH, et, al. Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4-([4- (1H-tetrazol-5-ylmethyl)phenoxy]methyl) phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4 and E4. Naunyn Schmiedebergs Arch Pharmacol. 1986 May;333(1):70-7. DOI:10.1007/BF00569663
[2] Bitterman H, et, al. Use of a novel peptide leukotriene receptor antagonist, Ly-163443, in splanchnic artery occlusion shock. Prostaglandins Leukot Essent Fatty Acids. 1988 May;32(2):63-70. DOI:10.1016/0952-3278(88)90097-x |
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