| Identification | More | [Name]
Ciprofloxacin lactate | [CAS]
97867-33-9 | [Synonyms]
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid lactate
CIPROFLOXACIN LACTATE
mono(2-hydroxypropanoate)
Ciprofloxacin lactate CP2000
85721-33-1
Ciprofloxacine lactate
CIPROFLOXACIN-QACID | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C20H22FN3O5 | [MDL Number]
MFCD01759747 | [Molecular Weight]
403.4 | [MOL File]
97867-33-9.mol |
| Hazard Information | Back Directory | [Uses]
Ciprofloxacin Lactate is an antibiotic that has been used to medicate polymer wound dressing. Ciprofloxacin Lactate has been shown to produce high and sustained serum bactericidal titers against highly susceptible bacteria. | [in vivo]
Ciprofloxacin (Bay-09867) lactate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague[3].
Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall[4].
Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall[4]. | Animal Model: | BALB/c mice[3] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal injection; for 24 hours | | Result: | Reduced the lung bacterial load in murine model of pneumonic plague. |
| Animal Model: | C57BL/6J mice[4] | | Dosage: | 100 mg/kg | | Administration: | Oral gavage; daily, for 4 weeks | | Result: | Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity. |
| Animal Model: | C57BL/6J mice[4] | | Dosage: | 100 mg/kg | | Administration: | Oral gavage; daily, for 4 weeks | | Result: | Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall. |
| [IC 50]
Quinolone |
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