| Identification | More | [Name]
Ropivacaine hydrochloride | [CAS]
98717-15-8 | [Synonyms]
n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide hydrochloride
ROPIVACAINE HCL
ROPIVACAINE HYDROCHLORIDE
ROPIVCACAINE HYDROCHLORIDE
(s)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
S-ROPIVACAINE HCL
(S)-ROPIVACAINE HYDROCHLORIDE
Ropivacaine mesilate
Ropivacaine hydrochloride | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C17H27ClN2O | [MDL Number]
MFCD02102164 | [Molecular Weight]
310.86 | [MOL File]
98717-15-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
260-262° | [alpha ]
D25 -6.6° (c = 2 in water) | [storage temp. ]
Store at -20°C | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
≥ 10.1mg/mL in Water | [Major Application]
pharmaceutical small molecule | [InChI]
InChI=1S/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H | [InChIKey]
NDNSIBYYUOEUSV-UHFFFAOYSA-N | [SMILES]
N1(CCC)CCCCC1C(NC1=C(C)C=CC=C1C)=O.[H]Cl | [CAS DataBase Reference]
98717-15-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
2-Piperidinecarboxamide hydrochloride is a useful research chemical compound. | [Uses]
anesthetic | [Definition]
ChEBI: The anhydrous form of (S)-ropivacaine hydrochloride. | [in vivo]
Epidural administration of Ropivacaine hydrochloride effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury[1].
Ropivacaine hydrochloride inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC)[2].
Ropivacaine hydrochloride prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats[2].
Ropivacaine hydrochloride inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs[2].
| Animal Model: | Adult Sprague-Dawley rats (300–400g)[2] | | Dosage: | 1 μM | | Administration: | Infusion (added to the perfusate reservoir) | | Result: | Attenuated pressure-dependent increases in filtration coefficient (Kf). |
| [storage]
Store at -20°C |
|
|