| Identification | Back Directory | [Name]
broussochalcone A | [CAS]
99217-68-2 | [Synonyms]
broussochalcone A
(E)-1-[2,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-3-(3,4-dihydroxyphenyl)-2-propen-1-one
2-Propen-1-one, 1-[2,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(3,4-dihydroxyphenyl)-, (2E)- | [Molecular Formula]
C20H20O5 | [MOL File]
99217-68-2.mol | [Molecular Weight]
340.37 |
| Chemical Properties | Back Directory | [Melting point ]
182-184 °C | [Boiling point ]
595.0±50.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.52±0.50(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways[1][2]. | [References]
[1] Cheng Z, et al. Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Biochem Pharmacol. 2001 Apr 15;61(8):939-46. DOI:10.1016/s0006-2952(01)00543-3
[2] Lee HK, et al. Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway. Oxid Med Cell Longev. 2021 Oct 27;2021:2800706. DOI:10.1155/2021/2800706 |
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