| Identification | More | [Name]
6-Bromo-1,3-dihydro-2H-indol-2-one | [CAS]
99365-40-9 | [Synonyms]
2H-INDOL-2-ONE, 6-BROMO-1,3-DIHYDRO-
6-BROMO-1,3-DIHYDRO-INDOL-2-ONE
6-BROMO-2-OXINDOLE
6-BROMO-2-OXYINDOLE
6-BROMOOXINDOLE
BROMOOXINDOLE (6-)
6-Bromo-1,3-dihydro-2H-indol-2-one
6-Bromooxoindole
6-Bromoxoindole
6-Bromo-1,3-dihydro-2H-indol-2-one 97%
6-bromoindolin-2-one | [EINECS(EC#)]
800-899-7 | [Molecular Formula]
C8H6BrNO | [MDL Number]
MFCD02179605 | [Molecular Weight]
212.04 | [MOL File]
99365-40-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yelllow crystal | [Melting point ]
217-221 °C(lit.)
| [Boiling point ]
343.6±42.0 °C(Predicted) | [density ]
1.666±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSo | [form ]
Solid | [pka]
13.39±0.20(Predicted) | [color ]
Orange | [Water Solubility ]
Slightly soluble in water. | [InChI]
InChI=1S/C8H6BrNO/c9-6-2-1-5-3-8(11)10-7(5)4-6/h1-2,4H,3H2,(H,10,11) | [InChIKey]
JARRYVQFBQVOBE-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC(Br)=C2)CC1=O | [CAS DataBase Reference]
99365-40-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
Light yelllow crystal | [Uses]
6-Bromo-2-Oxindole is an indolinone derivative used for the preparation of p38α inhibitors as potential antiinflammatories.
| [Synthesis]
The 2,5-dibromonitrobenzene was dissolved in DMF, ethyl acetoacetate and potassium carbonate were added and the reaction was carried out at 80 degrees Celsius; after that, 3 equivalents of iron were added and the reaction was carried out at 120 degrees |
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