| Identification | Back Directory | [Name]
5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER | [CAS]
99632-94-7 | [Synonyms]
RO 19-4603
Ro 194603,Ro 19 4603
5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylicacid1,1-dimethylethylester
5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
4H-Imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid, 5,6-dihydro-5-methyl-6-oxo-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H17N3O3S | [MDL Number]
MFCD00877822 | [MOL File]
99632-94-7.mol | [Molecular Weight]
319.38 |
| Hazard Information | Back Directory | [Uses]
Ro 19-4603 is a novel benzodiazepine inverse agonist. | [Definition]
ChEBI: Ro 19-4603 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and a tert-butyl ester. | [Biological Activity]
Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABA A receptors (K i values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats. | [in vivo]
Ro19-4603 (0-0.3 mg/kg, i.p.) markedly reduces EtOH intake at the 8-h interval in alcohol-preferring rats[1].
| Animal Model: | Alcohol-Preferring rats[1] | | Dosage: | 0.075, 0.150, and 0.30 mg/kg. | | Administration: | i.p. | | Result: | Reduced EtOH intake at the 8-h interval, but no apparent effect at the 24-h interval. |
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