102-02-3
102-02-3 结构式
基本信息
N-PHENYLIMINODICARBONIMIDIC-DIAMIDE
PHENYLBIGUANIDE
1-phenyl-biguanid
n-phenyl-n’-guanylguanidine
p1426
phenyl-biguanid
phenyldiguanide
2-(N2-Phenylamidino)guanidine
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-101331 | 1-苯基双胍 Phenylbiguanide | 102-02-3 | 10 mg | 303元 |
| 2025/02/08 | HY-101331 | 1-苯基双胍 Phenylbiguanide | 102-02-3 | 10mM * 1mLin DMSO | 333元 |
| 2025/02/08 | HY-101331 | 1-苯基双胍 Phenylbiguanide | 102-02-3 | 25 mg | 484元 |
常见问题列表
| Target | Value |
|
5-HT3 receptor
(Cell-free assay) | 3.0 μM(EC50) |
Phenylbiguanide (1-Phenylbiguanide) is a 5-HT 3 receptor selective agonist with pEC 50 s of 5.57, 4.07, and 4.47 for r5-HT 3A(b) , h5-HT 3A , m5-HT 3A(b) , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).
In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.