1132709-14-8
中文名称
硼替佐米杂质E
英文名称
((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid
CAS
1132709-14-8
分子式
C19H25BN4O4
分子量
384.24
MOL 文件
1132709-14-8.mol
更新日期
2025/07/01 11:31:59
1132709-14-8 结构式
基本信息
中文别名
硼替佐米杂质ES,S-异构体
硼替佐米杂质 19
硼替佐米(1S,2S)
硼替佐米杂质PS619
(1S,2S)-硼替佐米
(1S,2S)-硼替佐米杂质
BORTEZOMIB杂质 E
硼替佐米(1S,2S)异构体
硼替佐米杂质1(S,S-异构体)
英文别名
(1S,2S)-BortezoMibBortezomib (1S, 2S)
Bortezomib Impurity PS619
Bortezomib USP Impurity G
Bortezomib (1S,2S) isomer
(1S,2S)-Bortezomib Impurity
Bortezomib (1S,2S) Isomer Impurity
Bortezomib impurity 3/(1S,2S)-Bortezomib
N-(2-Pyrazinecarbonyl)-L-phenylalanine-D-leucine boronic anhydride
((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
密度1.214±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 50 mg/mL (130.13 mM; Need ultrasonic)
酸度系数(pKa)9.66±0.43(Predicted)
形态固体
颜色白色至灰白色
稳定性吸湿性
InChIKeyGXJABQQUPOEUTA-DOTOQJQBSA-N
SMILESB([C@H](NC(=O)[C@@H](NC(C1=NC=CN=C1)=O)CC1=CC=CC=C1)CC(C)C)(O)O
应用领域
用途1
(1S,2S)-Bortezomib is an isomer of Bortezomib (B675700), proteasome inhibitor. (1S,2S)-Bortezomib has been seen to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with A
lzheimer鈥檚 or hypertension.