1190332-25-2
1190332-25-2 结构式
基本信息
中文别名
化合物 T227565′-脱氧-5′-[4-[2-[(2,3-二氢-1-氧代-1H-异吲哚-4-基)氨基]-2-氧代乙基]-1-哌嗪基]-5′-氧代腺苷二盐酸盐
英文别名
EB47EB-47
EB47; EB-47价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/06/05 | HY-108631 | EB47; EB-47 EB-47 dihydrochloride | 1190332-25-2 | 5 mg | 1500元 |
| 2026/06/05 | HY-108631 | EB47; EB-47 EB-47 dihydrochloride | 1190332-25-2 | 10 mM * 1 mL in DMSO | 2014元 |
| 2026/06/05 | HY-108631 | EB47; EB-47 EB-47 dihydrochloride | 1190332-25-2 | 10 mg | 2500元 |
常见问题列表
生物活性
EB-47 dihydrochloride 是一种有效的 PARP-1/ARTD-1 选择性抑制剂，IC50 值为 45 nM，对 ARTD5 的IC50 值为 410 nM，表现出温和的效果。EB-47 模拟底物 NAD+，从烟酰胺延伸至腺苷亚区结合。体外研究
EB-47 dihydrochloride shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC 50 values of 0.86 and 1.0 µM, respectively.
体内研究
EB-47 dihydrochloride (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation.