123040-16-4
中文名称
盐酸阿扎司琼
英文名称
Azasetron hydrochloride
CAS
123040-16-4
分子式
C17H21Cl2N3O3
MDL 编号
MFCD00209913
分子量
386.27
MOL 文件
123040-16-4.mol
更新日期
2025/05/12 08:42:07
123040-16-4 结构式
基本信息
中文别名
盐酸阿扎司琼N-(1-氮杂双环[2.2.2]辛-8-基)-6-氯-4-甲基-3-氧代-3,4-二氢-2H-1,4-苯并恶嗪-8-甲酰胺盐酸盐
盐酸阿扎司琼
英文别名
AZASETRONAZASETRON HCL
AZASETRON HYDROCHLORIDE
N-1-AZABICYCLO[2.2.2]-OCT-3-YL-6-CHLORO-3,4-DIHYDRO-4-METHYL-3-OXO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE, HYDROCHLORIDE
N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-6-CHLORO-4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE HCL
N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-6-CHLORO-4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE HYDROCHLORIDE
Y-25130
Y-25130 HYDROCHLORIDE
2h-1,4-benzoxazine-8-carboxamide,3,4-dihydro-n-1-azabicyclo(2.2.2)oct-3-yl-6-c
N-(1-Azabicyclo[2,2,2]Oct-3-Yl)-6-Chloro-4-Methyl-3-Oxo-3,4-Dihydro-2h-1,4-Benzoxazine-8-Carboxamide HCl
N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-6-CHLORO-4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE HYDROCHLORIDE
Y-25130HCl
N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzo
INTERMEDIATE OF AZASETRON HCL
Serotone
Azasetron hydrochloride
N-(1-Azabicyclo[2.2.2]octan-8-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide hydrochloride
N-(1-Azabicyclo[2.2.2]octane-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide·hydrochloride
所属类别
原料药：止吐催吐药物理化学性质
外观白色粉末。
熔点281° (dec); mp 305° (dec) (Kawakita)
储存条件Sealed in dry,Room Temperature
溶解度甲醇（微溶）、水（微溶）
溶解度少许溶于甲醇和水
形态白色固体。
颜色白色
水溶解性H2O: 2mg/mL, clear
贮存方式-20℃低温保存.
原研厂家Japan Tobacco (Originator), Mitsubishi Pharma (Originator), Taiho (Not Determined), Torii (Marketer), Temis-Lostalo (Licensee).
盐酸阿扎司琼价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-B0068 | 盐酸阿扎司琼 Azasetron hydrochloride | 123040-16-4 | 5 mg | 375元 |
| 2025/02/08 | HY-B0068 | 盐酸阿扎司琼 Azasetron hydrochloride | 123040-16-4 | 10mg | 600元 |
| 2025/02/08 | HY-B0068 | 盐酸阿扎司琼 Azasetron hydrochloride | 123040-16-4 | 10mM * 1mLin Water | 660元 |
常见问题列表
生物活性
Azasetron HCl (Y-25130) 是一种选择性5-HT3受体拮抗剂，IC50为0.33 nM，用于癌症化疗引起的恶心和呕吐。靶点
| Target | Value |
| 5-HT3 | 0.33 nM |
体内研究
Azasetron could effectively penetrate through the skin and pass into the systemic circulation.
| Animal Model: | Four male Bama miniature pigs weighing 9-11 kg (15-16 weeks old). |
| Dosage: | 0.5 mg/kg. |
| Administration: | I.V. administration via the abdominal vein. |
| Result: | The mean plasma concentration dropped to minimum at 36 h. C max = 44.88 ± 7.16 ng/mL) was achieved at the time point of 66.00 ± 22.98 h (T max ). |