1239578-80-3
中文名称
化合物 NP-1815-PX
英文名称
1H-Naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione, 5-[3-(2,5-dihydro-5-thioxo-1,2,4-oxadiazol-3-yl)phenyl]-, sodium salt (1:1)
CAS
1239578-80-3
分子式
C21H15N4NaO3S
分子量
426.43
MOL 文件
1239578-80-3.mol
1239578-80-3 结构式
基本信息
中文别名
化合物 NP-1815-PX 英文别名
1H-Naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione, 5-[3-(2,5-dihydro-5-thioxo-1,2,4-oxadiazol-3-yl)phenyl]-, sodium salt (1:1)应用领域
用途一
NP-1815-PX is a novel antagonist selective for P2X4R with high potency and selectivity compared with other P2XR subtypes. In in vivo assay for acute and chronic pain, intrathecal administration of NP-1815-PX produced an anti-allodynic effect in mice with traumatic nerve damage without affecting acute nociceptive pain and motor function