125743-80-8
中文名称
氯雷他定杂质F
英文名称
Loratadine EP IMpurity F
CAS
125743-80-8
分子式
C22H24ClFN2O2
分子量
402.89
MOL 文件
125743-80-8.mol
更新日期
2025/09/04 13:14:00
125743-80-8 结构式
基本信息
中文别名
氯雷他定杂质F氯雷他定杂质06
氯雷他定EP杂质F
11-氟二氢氯雷他定
氯雷他定杂质F(EP)
氯雷他定杂质16(EP杂质F)
4-(8-氯-11-氟-6,11-二氢-5H-苯并[5,6]环庚[1,2-B]吡啶-11-基)-1-哌啶羧酸,乙酯
英文别名
FluoroloratadineEthyl 4-[(11RS)-8-chloro-11-fluoro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]piperidine-1-carboxylate
Loratadine EP IMpurity F
11-Fluoro Dihydroloratadine
OVPFJWGOZPZTKG-UHFFFAOYSA-N
Ethyl 4-[(11RS)-8-Chloro-11-fluoro-
Loratadine Impurity 4/Loratadine EP Impurity F
Loratadine Impurity 6(Loratadine EP Impurity F)
Ethyl 4-((11RS)-8-chloro-11-fluoro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidi
ethyl 4-(8-chloro-11-fluoro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine-1-carboxylate
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
熔点149-153 °C
沸点490.3±45.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
酸度系数(pKa)3.65±0.40(Predicted)
形态neat
InChIInChI=1S/C22H24ClFN2O2/c1-2-28-21(27)26-12-9-17(10-13-26)22(24)19-8-7-18(23)14-16(19)6-5-15-4-3-11-25-20(15)22/h3-4,7-8,11,14,17H,2,5-6,9-10,12-13H2,1H3
InChIKeyOVPFJWGOZPZTKG-UHFFFAOYSA-N
SMILESN1(C(OCC)=O)CCC(C2(F)C3=NC=CC=C3CCC3=CC(Cl)=CC=C32)CC1