128811-48-3
中文名称
BOC-D-焦谷氨酸甲酯
英文名称
(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE
CAS
128811-48-3
分子式
C11H17NO5
分子量
243.26
MOL 文件
128811-48-3.mol
更新日期
2025/08/11 14:17:46
128811-48-3 结构式
基本信息
中文别名
BOC-D-焦谷氨酸甲酯R-N-BOC-焦谷氨酸甲酯
N-BOC-D-焦谷氨酸甲酯
N-叔丁氧羰基-D-焦谷氨酸甲酯
N-叔丁氧羰基-L-焦谷氨酸甲酯
1-BOC-5-氧代-D -脯氨酸甲酯
(R)-N-BOC-5-甲氧羰基-2 - 吡咯烷酮
(R)-1-叔丁基2-甲基5-氧代吡咯烷-1,2-二羧酸酯
BOC-D-焦谷氨酸甲酯(CAS号:128811-48-3)
1-叔-丁基 2-甲基 (2R)-5-氧亚基吡咯烷-1,2-二甲酸基酯
英文别名
METHYL (R)-N-(TERT-BUTOXYCARBONYL)PYROGLUTAMATE1-tert-butyl 2-methyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate
utamic Acid MethyL
1-Boc-5-oxo-D-proline Methyl ester
Boc-L-pyroglutamic acid methyl ester
Boc-D-Pyroglutamic acid methyl ester
(R)-N-(tert-butoxycarbonyl)pyroglutaMate
(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE
(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE USP/EP/BP
-1-tert-Butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate
所属类别
生物化工：谷氨酸类衍生物物理化学性质
熔点68-69℃
沸点361.6±35.0 °C(Predicted)
密度1.209
储存条件under inert gas (nitrogen or Argon) at 2–8 °C
酸度系数(pKa)-4.28±0.40(Predicted)
外观White to off-white Solid
InChIInChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-7(9(14)16-4)5-6-8(12)13/h7H,5-6H2,1-4H3/t7-/m1/s1
InChIKeyFNTAOUUEQHKLIU-SSDOTTSWSA-N
SMILESN1(C(OC(C)(C)C)=O)C(=O)CC[C@@H]1C(OC)=O
制备方法
方法1
24424-99-5
68766-96-1
144978-12-1
以二碳酸二叔丁酯和D-焦谷氨酸乙酯为原料合成BOC-L-焦谷氨酸乙酯的一般步骤：将D-焦谷氨酸乙酯（5.1g，32.6mmol）溶于二氯甲烷（70ml）中，依次加入三乙胺（4.55ml，32.6mmol）、二碳酸二叔丁酯（14.2g，65.2mmol）和4-（二甲基氨基）吡啶（3.98g，32.6mmol）。将反应混合物在室温下搅拌1.5小时，通过薄层色谱（TLC）监测反应进程，确认反应完全。反应完成后，将反应液用水洗涤两次，再用盐水洗涤，有机相用无水硫酸钠干燥，过滤后减压浓缩。粗产物通过柱色谱法（洗脱剂比例为1:1的乙酸乙酯/石油醚）纯化，得到Boc-D-焦谷氨酸乙酯，为浅黄色粘稠油状物（7.98g，收率95%），静置后固化为固体。
参考文献：
[1] Patent: WO2007/36730, 2007, A1. Location in patent: Page/Page column 120
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1383 - 1393
[3] Patent: EP1847536, 2007, A1. Location in patent: Page/Page column 28
[4] Patent: US2009/48213, 2009, A1. Location in patent: Page/Page column 70-71
[5] Patent: US2011/34469, 2011, A1. Location in patent: Page/Page column 124
BOC-D-焦谷氨酸甲酯价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | XW1288114833 | BOC-D-焦谷氨酸甲酯 methyl n-(tert-butoxycarbonyl)-d-pyroglutamate;n-(tert-butoxycarbonyl)-d-pyroglutamic acid methyl ester;methyl (r)-n-(tert-butoxycarbonyl)pyroglutamate;methyl (r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate;methyl (r)-1-boc-5-oxopyrrolidine-2-carboxylate;(r)-1-boc-5-oxopyrrolidine-2-carboxylic acid methyl ester;(r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester;boc-d-pyroglutamic acid methyl ester;methyl n-boc-d-pyroglutamate;n-boc-d-pyroglutamic acid methyl ester;1-boc-5-oxo-d-proline methyl ester;(r)-1-tert-butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate;boc-d-pyr-ome | 128811-48-3 | 5G | 46元 |
| 2025/05/22 | XW1288114832 | BOC-D-焦谷氨酸甲酯 methyl n-(tert-butoxycarbonyl)-d-pyroglutamate;n-(tert-butoxycarbonyl)-d-pyroglutamic acid methyl ester;methyl (r)-n-(tert-butoxycarbonyl)pyroglutamate;methyl (r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate;methyl (r)-1-boc-5-oxopyrrolidine-2-carboxylate;(r)-1-boc-5-oxopyrrolidine-2-carboxylic acid methyl ester;(r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester;boc-d-pyroglutamic acid methyl ester;methyl n-boc-d-pyroglutamate;n-boc-d-pyroglutamic acid methyl ester;1-boc-5-oxo-d-proline methyl ester;(r)-1-tert-butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate;boc-d-pyr-ome | 128811-48-3 | 1G | 32元 |
| 2025/05/22 | XW1288114831 | BOC-D-焦谷氨酸甲酯 methyl n-(tert-butoxycarbonyl)-d-pyroglutamate;n-(tert-butoxycarbonyl)-d-pyroglutamic acid methyl ester;methyl (r)-n-(tert-butoxycarbonyl)pyroglutamate;methyl (r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate;methyl (r)-1-boc-5-oxopyrrolidine-2-carboxylate;(r)-1-boc-5-oxopyrrolidine-2-carboxylic acid methyl ester;(r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester;boc-d-pyroglutamic acid methyl ester;methyl n-boc-d-pyroglutamate;n-boc-d-pyroglutamic acid methyl ester;1-boc-5-oxo-d-proline methyl ester;(r)-1-tert-butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate;boc-d-pyr-ome | 128811-48-3 | 250MG | 30元 |