129-20-4
中文名称
羟保松
英文名称
OXYPHENYL BUTAZONE
CAS
129-20-4
EINECS 编号
204-936-2
分子式
C19H20N2O3
MDL 编号
MFCD00057278
分子量
324.37
MOL 文件
129-20-4.mol
129-20-4 结构式
基本信息
中文别名
羟保松羟布宗
羟基保泰松
羟基保泰松,坦特利尔,羟保松
英文别名
LABOTEST-BB LT00134684OXYPHENYL BUTAZONE
1-(p-Hydroxyphenyl)-2-phenyl-3,5-dioxo-4-N-butylpyrazolidine
1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione
1-(p-hydroxyphenyl)-2-phenyl-4-butylpyrazolidine-3,5-dione
1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine
1-phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine
1-p-hydroxyphenyl-2-phenyl-3,5-dioxo-4-n-butylpyrazolidine
3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene
3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl-
3,5-Pyrazolidinedione, 4-butyl-1-(p-hydroxyphenyl)-2-phenyl-
3,5-pyrazolidinedione,4-butyl-1-(4-hydroxyphenyl)-2-phenyl
4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
4-butyl-1-(p-hydroxyphenyl)-2-phenyl-5-pyrazolidinedione
4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine
4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione
Artroflog
BM 1
bm1
所属类别
原料药：非甾抗炎药物理化学性质
外观性状白色结晶或结晶性粉末。熔点124-125℃。易溶于乙醇、丙酮，溶于氯仿、苯、醚，不溶于水。易溶于氢氧化碳或碳酸碱溶液。无臭，味苦。
熔点109-111°C
沸点462.71°C (rough estimate)
密度1.2118 (rough estimate)
折射率1.6140 (estimate)
储存条件-20°C
溶解度DMSO：可溶10mg/mL，澄清
酸度系数(pKa)pKa 4.7/10.0±0.2(H2O,t =25,Iundefined) (Uncertain)
形态粉末
颜色白色至棕色
水溶解性20mg/L(room temperature)
稳定性吸湿性
(IARC)致癌物分类3 (Vol. 13, Sup 7) 1987
羟保松价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-B1355A | 羟保松 Oxyphenbutazone | 129-20-4 | 5 mg | 750元 |
| 2025/02/08 | HY-B1355A | 羟保松 Oxyphenbutazone | 129-20-4 | 10mg | 1200元 |
| 2025/02/08 | HY-B1355A | 羟保松 Oxyphenbutazone | 129-20-4 | 10 mM * 1 mLin DMSO | 1320元 |
常见问题列表
生物活性
Oxyphenbutazone 是一种苯丁酮衍生物，具有抗炎作用。Oxyphenbutazone 是一种非选择性的 COX 抑制剂。Oxyphenbutazone 能选择性地杀死不复制的结核分枝杆菌。靶点
COX
体外研究
Oxyphenbutazone enhances the anticancer efficiency of methotrexate (MTX) in Hep3B cells.
Oxyphenbutazone (2.5 -7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells.
Oxyphenbutazone exhibits reparative effects in the hepatocytes.
Cell Cytotoxicity Assay
| Cell Line: | Hep3B cells |
| Concentration: | 2.5 µM, 5 µM, 7.5 µM |
| Incubation Time: | 48 hours |
| Result: | Enhanced the cytotoxicity of MTX. |
体内研究
Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).
| Animal Model: | 5–6 weeks Wistar strain albino male rats (150–220 g) |
| Dosage: | 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week) |
| Administration: | Oral administration; once a week; in two divided doses; for 13 weeks |
| Result: | Exerted potential anticancer activity in rats when co-treatment with MTX. |