129277-38-9
中文名称
党参炔苷
英文名称
Lobetyolin
CAS
129277-38-9
分子式
C20H28O8
分子量
396.44
MOL 文件
129277-38-9.mol
更新日期
2025/12/15 09:26:42
129277-38-9 结构式
基本信息
英文别名
β-D-Glucopyranoside, (1R,2R,7E)-2-hydroxy-1-[(1E)-5-hydroxy-1-pentenyl]-7-nonene-3,5-diynyl (9CI) 所属类别
生物化工：核苷类药物物理化学性质
沸点698.5±55.0 °C(Predicted)
密度1.35±0.1 g/cm3(Predicted)
酸度系数(pKa)11.39±0.20(Predicted)
形态Solid
颜色White to yellow
InChIKeyMMMUDYVKKPDZHS-FHMAEMBXNA-N
SMILESO([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]([H])(/C=C/CCCO)[C@H](O)C#CC#C/C=C/C |&1:1,2,3,5,7,12,20,r|
党参炔苷价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/06/05 | HY-N0327 | 党参炔苷 Lobetyolin | 129277-38-9 | 5 mg | 1204元 |
| 2026/06/05 | HY-N0327 | 党参炔苷 Lobetyolin | 129277-38-9 | 10 mM * 1 mL in DMSO | 1324元 |
| 2026/06/05 | HY-N0327 | 党参炔苷 Lobetyolin | 129277-38-9 | 10 mg | 1998元 |
常见问题列表
生物活性
Lobetyolin 是一种分离自 Codonopsis pilosula 的生物活性化合物。Lobetyolin 具有抗炎，抗氧化和黄嘌呤氧化酶抑制活性。Lobetyolin 还通过抑制 ASCT2 介导的谷氨酰胺代谢来诱导细胞凋亡。体外研究
Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. MUC5AC gene expression induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells is inhibited by pretreatment with Lobetyolin, lobetyol or methyl linoleate. Lobetyolin does not affect PMA-induced MUC5AC production from NCI-H292 cells. The amounts of mucin in the cells of Lobetyolin-treated cultures are 100±25%, 487±33%, 524±38%, 411±24%, and 402±45% for control, 10 ng/mL of PMA alone, PMA plus Lobetyolin 1 μM, PMA plus Lobetyolin 10 μM, and PMA plus Lobetyolin 100 μM, respectively.