13748-90-8
13748-90-8 结构式
基本信息
S-2-羟基-4-甲基戊酸
2-羥-4-甲[基]戊酸
白羥酸
Α-羥異己酸
2-HYDROXY-3-METHYLVALERIC ACID
L-ALPHA-HYDROXYISOCAPROIC ACID
LEUCIC ACID
L-LEUCIC ACID
(S)-2-HYDROXY-4-METHYLVALERIC ACID
(S)-(-)-2-HYDROXYISOCAPROIC ACID
(s)-pentanoicaci
L-2-hydroxy-4-methylvaleric acid
(S)-(-)-2 HYDROXYSOCAPROIC ACID,98%
Pentanoic acid, 2-hydroxy-4-methyl-, (2S)-
(2S)-2-hydroxy-4-methylpentanoic acid
Hydroxyisocaproic acid
L-LEUCIC ACID ( AKA ) 2-HYDROXY ISOCAPROIC ACID
S-2-Hydroxy-4-methylpentanoic acid
(S)-Leucic acid
2-Hydroxy-4-methylvaleric acid, L-2-Hydroxy-4-methylpentanoic acid, L-Leucic acid
(2S)-2-Hydroxy-4-methylvaleric acid
(S)-4-Methyl-2-hydroxyvaleric acid
物理化学性质
制备方法
61-90-5
13748-90-8
一般步骤：将L-亮氨酸（24.92 g，0.189 mol）溶于1.25 M H2SO4（125 mL）中，搅拌并冷却至0℃。在搅拌下，逐滴加入亚硝酸钠（19.73 g，0.286 mol）的水溶液（100 mL）。加毕，将反应混合物在0℃下继续搅拌2小时，随后升至室温搅拌15小时。反应完成后，用乙醚（6×75 mL）萃取反应混合物。合并有机层，用无水MgSO4干燥，过滤后减压浓缩除去乙醚，得到粗产物L-α-羟基异己酸（2c或2d）。粗产物通过己烷-乙醚混合溶剂重结晶纯化。
参考文献：
[1] Organic Letters, 2012, vol. 14, # 16, p. 4246 - 4249
[2] Organic Letters, 2006, vol. 8, # 14, p. 2993 - 2996
[3] European Journal of Organic Chemistry, 2009, # 31, p. 5390 - 5405
[4] ACS Chemical Neuroscience, 2013, vol. 4, # 8, p. 1204 - 1216
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 1, p. 11 - 14
常见问题列表
L-alpha-羟基异己酸是一种基于隐藻霉素的大环二肽的合成试剂，用作微管蛋白抑制剂。
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Human Endogenous Metabolite
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| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | 20481 | L-alpha-羟基异己酸 1GR L-alpha-Hydroxyisocaproic acid, 98%, Thermo Scientific Chemicals | 13748-90-8 | 1g | 611元 |
| 2025/05/22 | 20481 | L-alpha-羟基异己酸 1GR L-alpha-Hydroxyisocaproic acid, 98%, Thermo Scientific Chemicals | 13748-90-8 | 5g | 2052元 |
| 2025/05/22 | HY-30216A | L-alpha-羟基异己酸 Leucic acid | 13748-90-8 | 250 mg | 175元 |