1513879-18-9
中文名称
KAI407;KAI-407;KAI 407
英文名称
KAI407
CAS
1513879-18-9
分子式
C22H14F3N5O
分子量
421.37
MOL 文件
1513879-18-9.mol
1513879-18-9 结构式
应用领域
用途一
KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM). KAI407 may represent a new compound class for P. vivax malaria prophylaxis and potentially a radical cure.