18696-26-9
中文名称
芥子碱
英文名称
Sinapine
CAS
18696-26-9
分子式
[C16H24NO5]+.
MOL 文件
18696-26-9.mol
更新日期
2025/08/20 14:17:18
18696-26-9 结构式
基本信息
中文别名
芥子碱(标准品) 英文别名
SinapinSinapic acid choline ester
2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium
2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethylethanaminium
Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-
Ethanaminium,2-[[3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propen-1-yl]oxy]-N,N,N-trimethyl-
2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-2-[[3-(4-Hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl]oxy]-N,N,N-trimethylethanaminium
所属类别
分析化学：中药标准品物理化学性质
熔点178℃
储存条件4°C, away from moisture and light
溶解度DMSO : 250 mg/mL (805.52 mM; Need ultrasonic)
形态粉末
颜色Off-white to yellow
InChIInChI=1S/C16H23NO5/c1-17(2,3)8-9-22-15(18)7-6-12-10-13(20-4)16(19)14(11-12)21-5/h6-7,10-11H,8-9H2,1-5H3/p+1
InChIKeyHUJXHFRXWWGYQH-UHFFFAOYSA-O
SMILESC1(O)=C(OC)C=C(C=C1OC)/C=C/C(OCC[N+](C)(C)C)=O
LogP-3.370 (est)
常见问题列表
生物活性
Sinapine 是一种从十字花科物种的种子中分离出来的生物碱，具有抗氧化、抗肿瘤和放射防护的作用。Sinapine 通过下调 P-glycoprotein 来抑制Caco-2细胞的增殖。靶点
| Target | Value |
|
P-glycoprotein
() |
体外研究
Sinapine (6 or 60 μM; 1 h) counteracts H
2
O
2
and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes.
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity.
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease.
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.
体内研究
Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.