188860-26-6
188860-26-6 结构式
基本信息
中文别名
2'-(3,4-二甲氧基苯基)-5-(4-甲基哌嗪-1-基)-1H,1'H-2,5'-联苯并[D]咪唑2'-(3,4-二甲氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-双[1H-苯并咪唑](DMA)
2'-(3,4-二甲氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-双[1H-苯并咪唑](DMA)
2'-(3,4-二甲氧基苯基)-5-(4-甲基哌嗪-1-基)-1H,1'H-2,5'-联苯并[D]咪唑
英文别名
2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)-物理化学性质
熔点220 °C
沸点737.3±70.0 °C(Predicted)
密度1.292±0.06 g/cm3(Predicted)
储存条件Sealed in dry,2-8°C
溶解度DMSO : ≥ 54 mg/mL (115.25 mM);
酸度系数(pKa)10.78±0.10(Predicted)
形态粉末
颜色Light brown to brown
外观Solid Powder
常见问题列表
生物活性
DMA 是一种荧光化合物 (λex=340 nm, λem=478 nm)。靶点
IC50: 3.4 μM (HeLa cell), 5.3 μM (MCF7 cell)
体外研究
The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC 50 is observed at 5.3 μM for DMA. The IC 50 determined in the case of HeLa is 3.4 μM for DMA.