1995893-58-7
中文名称
FEN1 Inhibitor C2
英文名称
FEN1 Inhibitor C2
CAS
1995893-58-7
分子式
C12H12N2O3
分子量
232.24
MOL 文件
1995893-58-7.mol
更新日期
2025/05/26 12:08:42
1995893-58-7 结构式
基本信息
中文别名
1-(环丙基甲基)-3-羟基喹唑啉-2,4(1H,3H)-二酮 英文别名
FEN1-IN-4FEN1 Inhibitor C2
2,4(1H,3H)-Quinazolinedione, 1-(cyclopropylmethyl)-3-hydroxy-
物理化学性质
储存条件Inert atmosphere,Store in freezer, under -20°C
溶解度DMSO: 125 mg/mL (538.24 mM)
形态Solid
颜色Light yellow to yellow
FEN1 Inhibitor C2价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-136485 | FEN1-IN-4 | 1995893-58-7 | 1 mg | 419元 |
| 2025/05/22 | HY-136485 | FEN1 Inhibitor C2 FEN1-IN-4 | 1995893-58-7 | 5mg | 1000元 |
| 2025/05/22 | HY-136485 | FEN1 Inhibitor C2 FEN1-IN-4 | 1995893-58-7 | 10mM * 1mLin DMSO | 1070元 |
常见问题列表
生物活性
FEN1-IN-4 (Compound 2) 是一种人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。靶点
hFEN1
体外研究
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.