217087-09-7
中文名称
埃索美拉唑镁(三水)
英文名称
Esomeprazole magnesium trihydrate
CAS
217087-09-7
分子式
C34H42MgN6O9S2
MDL 编号
MFCD07698573
分子量
767.17
MOL 文件
217087-09-7.mol
更新日期
2025/05/14 13:40:43
217087-09-7 结构式
基本信息
中文别名
埃索美拉唑镁(三水)二(5-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亚磺酰基]-1H-苯并咪唑-1-基)镁盐三水合物
英文别名
bis(5-methoxy-2-[(s)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1h-benzylimidazole-1-yl) magnesium trihydrateESOMEPRAZOLE MAGNESIUM
ESOMEPRAZOLE MAGNESIUM TRIHYDRATE
(T-4)-Bis[5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolato]magnesium
Nexium
ESOPMEPRAZOLE MG TRIHYDRATE
Bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzylimidazole-1-yl) magnesium trihydrate
ESOMEPRAZOLE MAGNESIUM TRIHYDRATE USP
物理化学性质
熔点184-189°C (dec.)
储存条件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度微溶于水，溶于甲醇，几乎不溶于庚烷。
形态neat
颜色White to off-white
InChIInChI=1S/2C17H18N3O3S.Mg.H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h2*5-8H,9H2,1-4H3;;1H2/q2*-1;+2;
InChIKeyVEVZQDGATGBLIC-UHFFFAOYSA-N
SMILESC(C1N=CC(C)=C(OC)C=1C)S1C2[N-]C3=CC(OC)=CC=C3N=2[Mg+2]2(O=S(CC3N=CC(C)=C(OC)C=3C)C3[N-]C4=CC(OC)=CC=C4N2=3)O=1.O
常见问题列表
用途
奥美拉唑的S形式。胃质子泵抑制剂。
生物活性
Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种有效的具有口服活性 H+, K+-ATPase 抑制剂，可用于上消化道疾病和胃食管反流疾病的研究。Esomeprazole magnesium trihydrate 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。靶点
H + , K + -ATPase
体外研究
Esomeprazole magnesium trihydrate is develped from Esomeprazole strontium tetrahydrate (EST). EST contains esomeprazole, the S-enantiomer of omeprazole a salt-exchanged version of Esomeprazole magnesium trihydrate.
体内研究
Esomeprazole magnesium (0.5-50 mg/kg; oral gavage; daily; for 10 days; A/J mice) treatment increases gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity.
| Animal Model: | A/J mice |
| Dosage: | 0.5 mg/kg, 5 mg/kg, 50 mg/kg |
| Administration: | Oral gavage; daily; for 10 days |
| Result: | Gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity are increased. |