2271035-37-9
中文名称
FC 11
英文名称
1H-1,2,3-Triazole-4-carboxamide, 1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-
CAS
2271035-37-9
分子式
C41H42F3N13O9S
分子量
949.91
MOL 文件
2271035-37-9.mol
2271035-37-9 结构式
基本信息
英文别名
1H-1,2,3-Triazole-4-carboxamide, 1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-物理化学性质
密度1.57±0.1 g/cm3(Predicted)
溶解度Soluble to 100 mM in DMSO
酸度系数(pKa)10.60±0.70(Predicted)
形态Solid
颜色Light yellow to yellow
应用领域
用途一
FC-11 is a potent FAK-targeting PROTAC. FC-11 showed a rapid and reversible FAK degradation with a picomolar of DC50 in various cell lines in vitro, which imply that FAK-PROTACs could be useful as expand tools for studying functions of FAK in biological system and as potential therapeutic agents.