2351898-91-2

中文名称 8pyDTZ

英文名称 8pyDTZ

CAS 2351898-91-2

分子式 C24H18N4O

分子量 378.43

MOL 文件 2351898-91-2.mol

2351898-91-2 结构式

基本信息物理化学性质 8pyDTZ价格(试剂级) 常见问题列表

基本信息

中文别名

化合物 T19167

英文别名

8pyDTZ

物理化学性质

沸点556.7±60.0 °C(Predicted)

密度1.26±0.1 g/cm3(Predicted)

储存条件Store at -20°C,unstable in solution, ready to use.

溶解度DMSO: 12.5 mg/mL (33.03 mM; DMSO can inactivate 8pyDTZ's activity); EtOH+HCl: 2 mg/mL (5.28 mM; ultrasonic and adjust pH to 2 with 1M HCl; DMSO can inactivate 8pyDTZ's activity)

酸度系数(pKa)6.54±0.10(Predicted)

形态Solid

颜色Light brown to brown

水溶解性Water: < 0.1 mg/mL (insoluble; DMSO can inactivate 8pyDTZ's activity)

8pyDTZ价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-135368	8pyDTZ	2351898-91-2	1 mg	2045元
2025/12/22	HY-135368	8pyDTZ 8pyDTZ	2351898-91-2	5mg	4500元
2024/08/19	HY-135368	8pyDTZ 8pyDTZ	2351898-91-2	10mg	6800元

常见问题列表

生物活性

8pyDTZ 是一种吡啶基二苯基叔嗪 (DTZ) 类似物，也是一种 LumiLuc 荧光素酶的 ATP 非依赖性吡啶基底物。8pyDTZ 表现出光谱偏移的发射并改善了水溶性。8pyDTZ 具有出色的生物相容性和体内敏感性，可用于生物体内发光成像。

体外研究

Compared to DTZ, 8pyDTZ (compounds 3c) is able to emit red-shifted chemiluminescence or bioluminescence. 8pyDTZ shows the most red-shifted emission and red-shifted photons can penetrate through tissue better.
LumiLuc-8pyDTZ in human embryonic kidney (HEK) 293T cells transiently expressing the luciferase is evaluated. The LumiLuc-8pyDTZ pair produces ∼3-5-fold more bioluminescence than teLuc-8pyDTZ. To compare far-red emission intensities of bioluminescent reporters, HEK 293T cells in the presence of a 600-700 nm band pass filter are imaged. At substrate concentrations from 6.25 to 100 μM, LumiLuc-8pyDTZ consistently produces 1.6-3.9-fold higher photon flux than teLuc-DTZ. No ATP perturbation is observed from 8pyDTZ-treated, LumiLucexpressing cells.

体内研究

LumiLuc-8pyDTZ pair is compared with several benchmark reporters in a tumor xenograft mouse model. LumiLuc-8pyDTZ shows high sensitivity and does not need organic cosolvents for in vivo administration. LumiScarlet-8pyDTZ is comparable to Akaluc-AkaLumine, the brightest ATP-dependent luciferase-luciferin pair, for detecting cells in deep tissues of mice.