| Chemical Properties | Back Directory | [Boiling point ]
556.7±60.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
DMSO: 12.5 mg/mL (33.03 mM; DMSO can inactivate 8pyDTZ's activity); EtOH+HCl: 2 mg/mL (5.28 mM; ultrasonic and adjust pH to 2 with 1M HCl; DMSO can inactivate 8pyDTZ's activity) | [form ]
Solid | [pka]
6.54±0.10(Predicted) | [color ]
Light brown to brown | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble; DMSO can inactivate 8pyDTZ's activity) |
| Hazard Information | Back Directory | [Uses]
8pyDTZ is a pyridyl diphenylterazine (DTZ) analog and an ATP-independent pyridyl substrate of LumiLuc luciferase. 8pyDTZ exhibits spectrally shifted emission. 8pyDTZ has excellent biocompatibility and superior in vivo sensitivity. 8pyDTZ can be used for in vivo luminescence imaging[1]. | [in vivo]
LumiLuc-8pyDTZ pair is compared with several benchmark reporters in a tumor xenograft mouse model. LumiLuc-8pyDTZ shows high sensitivity and does not need organic cosolvents for in vivo administration. LumiScarlet-8pyDTZ is comparable to Akaluc-AkaLumine, the brightest ATP-dependent luciferase-luciferin pair, for detecting cells in deep tissues of mice[1]. | [References]
[1] Yeh HW, et al. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019 May 17;14(5):959-965. DOI:10.1021/acschembio.9b00150 |
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