23567-97-7

中文名称 8-BROMO-ATP

英文名称 8-bromoadenosine 5'-triphosphate

CAS 23567-97-7

分子式 C10H15BrN5O13P3

分子量 586.08

MOL 文件 23567-97-7.mol

23567-97-7 结构式

基本信息物理化学性质常见问题列表

基本信息

英文别名

8-bromoadenosine 5'-triphosphate
Adenosine 5'-(tetrahydrogen triphosphate), 8-bromo-

物理化学性质

沸点983.1±75.0 °C(Predicted)

密度2.85±0.1 g/cm3(Predicted)

酸度系数(pKa)0.97±0.50(Predicted)

常见问题列表

生物活性

8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate)，一种 ATP 类似物，是一种嘌呤能 P2X receptor 受体的激动剂。8-Bromo-ATP 对多发性骨髓瘤细胞具有细胞毒性，IC50 为 23.1 μM。

体外研究

8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma.
Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations.

Cell Viability Assay

Cell Line:	MM 1.s cells
Concentration:	10 μM, 20 μM, 30 μM, 40 μM, 50 μM
Incubation Time:	5 days
Result:	Showed cytotoxic to multiple myeloma.