| Identification | Back Directory | [Name]
8-bromoadenosine 5'-triphosphate | [CAS]
23567-97-7 | [Synonyms]
8-bromoadenosine 5'-triphosphate
Adenosine 5'-(tetrahydrogen triphosphate), 8-bromo- | [Molecular Formula]
C10H15BrN5O13P3 | [MDL Number]
MFCD28010257 | [MOL File]
23567-97-7.mol | [Molecular Weight]
586.08 |
| Hazard Information | Back Directory | [Uses]
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM[1][2][3]. | [References]
[1] Howson, W, et al. Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder). Eur. J. Med. Chem. 23(5), 433-439 (1988).
[2] P Champeil, et al. ATP regulation of sarcoplasmic reticulum Ca2+-ATPase. Metal-free ATP and 8-bromo-ATP bind with high affinity to the catalytic site of phosphorylated ATPase and accelerate dephosphorylation. J Biol Chem. 1988 Sep 5;263(25):12288-94. PMID:2970458
[3] Li Wang, et al. Cationic phospholiposomes: efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells. J Liposome Res. 2011 Dec;21(4):306-14. DOI:10.3109/08982104.2011.565476 |
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