2407860-35-7
中文名称
化合物ERSO
英文名称
2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)-
CAS
2407860-35-7
分子式
C22H13F6NO3
分子量
453.33
MOL 文件
2407860-35-7.mol
2407860-35-7 结构式
基本信息
中文别名
化合物ERSO化合物 ERSO-DFP
英文别名
ErSOErSo-DFP
2H-Indol-2-one, 1,3-dihydro-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-, (3R)-
物理化学性质
沸点485.0±45.0 °C(Predicted)
密度1.461±0.06 g/cm3(Predicted)
溶解度DMSO: Soluble
Methanol: Soluble
Methanol: Soluble
酸度系数(pKa)9?+-.0.30(Predicted)
形态Solid
颜色White to off-white
应用领域
用途一
ErSO is an activator of the unfolded protein response which eradicates human breast tumors in mice. ErSO activates the anticipatory unfolded protein response (a-UPR) and induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro. In multiple orthotopic models, ErSO treatment given either orally or intraperitoneally for 14 to 21 days induced tumor regression without recurrence. In a cell line tail vein metastasis model, ErSO was also effective at inducing regression of most lung, bone, and liver metastases. ErSO treatment induced almost complete regression of brain metastases in mice carrying intracranial human breast cancer cell line xenografts.