2448475-08-7
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-102047B | KDOAM-25 (citrate) KDOAM-25 citrate | 2448475-08-7 | 5mg | 1000元 |
| 2025/02/08 | HY-102047B | KDOAM-25 (citrate) KDOAM-25 citrate | 2448475-08-7 | 10mM * 1mLin DMSO | 1100元 |
| 2025/02/08 | HY-102047B | KDOAM-25 (citrate) KDOAM-25 citrate | 2448475-08-7 | 10mg | 1800元 |
常见问题列表
IC50: 71 nM (KDM5A), 19 nM (KDM5B), 69 nM (KDM5C), 69 nM (KDM5D)
KDOAM-25 citrate inhibits most potently KDM5B with an IC
50
of ∼50 μM and the other KDM5 family members at concentrations above 100 μM. KDOAM-25 citrate shows no cellular activity on any of the other tested JmjC family members.
KDOAM-25 citrate is able to reduce the viability of MM1S cells with an IC
50
of ∼30 μM after a delay of 5-7 days.
KDOAM-25 citrate treatment results in a G1 cell-cycle arrest with an increased proportion of MM1S in G1 and a decrease of the proportion of cells in G2 without an increase in the proportion of cells in the apoptotic sub-G1 phase.
KDOAM-25 citrate (50 μM) increases with approximately twice as much H3K4me3 in in multiple myeloma cells.