265646-85-3

中文名称 ENDOVION

英文名称 Endovion

CAS 265646-85-3

分子式 C16H9BrF6N6O

分子量 495.18

MOL 文件 265646-85-3.mol

更新日期 2025/05/12 10:48:36

265646-85-3 结构式

基本信息物理化学性质安全数据图谱信息 ENDOVION价格(试剂级) 常见问题列表

基本信息

中文别名

化合物ENDOVION
1-(3,5-双(三氟甲基)苯基)-3-(4-溴-2-(2H-四唑-5-基)苯基)脲

英文别名

NS3728
Endovion
NS3728 >=98% (HPLC)
Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-

物理化学性质

密度1.791±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度Soluble to 100 mM in DMSO and to 50 mM in ethanol

酸度系数(pKa)3.95±0.10(Predicted)

形态Solid

颜色White to off-white

水溶解性Water : < 0.1 mg/mL (insoluble)

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H315-H319

防范说明P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

图谱信息

ENDOVION(265646-85-3)核磁图(¹HNMR)

ENDOVION价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/02/08	HY-105917	ENDOVION Endovion	265646-85-3	5mg	500元
2025/02/08	HY-105917	ENDOVION Endovion	265646-85-3	10mM * 1mLin DMSO	545元
2025/02/08	HY-105917	ENDOVION Endovion	265646-85-3	10mg	770元

常见问题列表

生物活性

Endovion (NS3728) 是一种阴离子通道抑制剂 (如氯离子通道)，也是特异性的 VRAC/VSOAC 阻断剂。Endovion (NS3728) 还是一种 ANO1 抑制剂。

靶点

Chloride channel, VRAC/VSOAC.
ANO1.

体外研究

Endovion (NS3728, 10-100 μM) reduces TNFα-induced apoptosis and increases p53-protein level as well as downstream signaling, e.g., expression of p21 ^Waf1/Cip1 , Bax, Noxa, MDM2, and activation of Caspase-9/-3 in Cisplatin-sensitive cells.
Endovion (NS3728, 10 μM) inhibits cell proliferation in Capan-1, AsPC-1 and BxPC-3 cell lines.

Western Blot Analysis

Cell Line:	Wild-type, resistant, and transiently transfected A2780 cells.
Concentration:	10-100 μM.
Incubation Time:	18 or 4.5 h.
Result:	Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells. Resulted in an increased LRRC8A protein expression. Significantly reduceed p53 and ^p21Waf1/Cip1 protein level in A2780WT cells.

Cell Proliferation Assay

Cell Line:	Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines.
Concentration:	10 μM.
Incubation Time:	24 h.
Result:	Resulted in the most pronounced inhibition in all cell lines with 77 ± 26 % in Capan-1, 67 ± 9 % in AsPC-1, and 54 ± 8 % in BxPC-3 cells at +67 mV.