27387-31-1
27387-31-1 结构式
基本信息
9-甲基-1,2,3,4-四氢咔唑酮
1,2,3,9-四氢-9-甲基-4H-咔唑酮
N-甲基四氢咔唑酮
1,2,3,4-四氢-9-甲基咔唑-4-酮
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE
1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONE
1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOLE-4-ONE
1,2,3,9-TETRAHYDRO-9-METHYL CARBAZOLE-4-ONE
9-METHYL-1,2,3,4-TETRAHYDRO-4-OXOCARBAZOLE
9-METHYL-1,2.3,4-TETRAHYDRO-4-OXOCARBAZOLE-4-ONE
9-METHYL-1,2,3,9-TETRAHYDRO-4H-CARBAZOL-4-ONE
9-METHYL-1,2,3,9-TETRAHYDRO-CARBAZOL-4-ONE
9-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-4-ONE
1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One99%
N-Methylcarbazolone
1,2,3,9-Tetrahydro-9-Methyl-4H
1,2,3,4-TETRAHYDRO-9-METHCARBAZOL-4-ONE
1,2,3,9-Tetrahydro-4H-9-methyl-carbazole-4-one
N-METHYL-4-OXO-1,2,3,4-TETRAHYDROCARBAZOLE
1,2,3,4-tetrahydro-4-oxocarbazolt
1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONEONDANSETRON
物理化学性质
安全数据
制备方法
15128-52-6
4637-24-5
27387-31-1
以2,3-二氢-1H-咔唑-4(9H)-酮（1.0 mmol）和N,N-二甲基甲酰胺二甲基缩醛（10 mmol）为原料，在N,N-二甲基甲酰胺（5.0 mL）中回流反应1.0小时。反应完成后，将混合物冷却至室温，用乙酸乙酯（2×25 mL）萃取。分离有机层，用饱和盐水溶液洗涤，随后用无水Na2SO4干燥。减压浓缩除去溶剂，所得固体用乙醇重结晶，得到白色针状晶体，收率71%，熔点188-190℃。IR（cm-1）: 1695（C=O）。1H NMR（400 MHz, CDCl3）δ: 2.24-2.27（t, 2H, CH2, J = 6.28 Hz）, 2.56-2.59（t, 2H, CH2, J = 6.0 Hz）, 2.91-2.94（t, 2H, CH2, J = 6.21 Hz）, 3.70（s, 3H, NCH3）, 7.27-7.30（m, 3H, Ph）, 8.24-8.26（m, 1H, Ph）。元素分析计算值（C13H13NO）: C, 78.36; H, 6.58; N, 7.03%。实测值: C, 78.29; H, 6.49; N, 6.92%。
参考文献：
[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53B, # 12, p. 1606 - 1610
[2] Journal of Molecular Structure, 2014, vol. 1080, p. 137 - 144
[3] Russian Chemical Bulletin, 2005, vol. 54, # 8, p. 1887 - 1891