335165-68-9
中文名称
BAI1
英文名称
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
CAS
335165-68-9
分子式
C19H21Br2N3O
分子量
467.2
MOL 文件
335165-68-9.mol
更新日期
2025/09/05 13:40:31
335165-68-9 结构式
基本信息
中文别名
1-(3,6-二溴-9H-咔唑-9-基)-3-(哌嗪-1-基)丙-2-醇3,6-二溴吲哚-ALPHA-(1-哌嗪甲基)-9H-咔唑-9-乙醇双盐酸盐
英文别名
Bax channel blocke)-3-(piperazin-1-yL
BAX CHANNEL BLOCKER
Baxchannelblocker2HCl
1-(3,6-Dibromo-9H-carbazoL
Bax channel blocker(BAI-1)
9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol
3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
所属类别
生物化工：抑制剂物理化学性质
沸点388.1±42.0 °C(Predicted)
密度1.71±0.1 g/cm3(Predicted)
储存条件Keep in dark place,Inert atmosphere,Room temperature
溶解度≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
酸度系数(pKa)14.48±0.20(Predicted)
形态固体
颜色白色
InChIInChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H
InChIKeyHWFKCAFKXZFOQT-UHFFFAOYSA-N
SMILESC12=CC=C(Br)C=C1C1=C(C=CC(Br)=C1)N2CC(O)CN1CCNCC1.Cl.Cl
BAI1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/09/19 | S8865 | BAI1 BAI1 | 335165-68-9 | 5mg | 876.42元 |
| 2025/09/19 | S8865 | BAI1 | 335165-68-9 | 10mM (1mL in DMSO) | 1040.13元 |
| 2025/09/19 | S8865 | BAI1 BAI1 | 335165-68-9 | 25mg | 2760.43元 |
常见问题列表
生物活性
BAI1是一种直接的BAX变构抑制剂，Kd值为15.0 ± 4 μM。靶点
| Target | Value |
|
Bax
(Cell-free assay) | 15.0 μM(Kd) |
体外研究
BAI1 selectively inhibits BAX-mediated apoptotic cell death.
BAI1 shows inhibition of tBID (HY-100464)-induced BAX-mediated membrane permeabilization in a dose dependent manner with an IC
50
of 3.3 μΜ.
Apoptosis Analysis
| Cell Line: | Mouse MEF |
| Concentration: | 0.3125 μM , 0.625 μM, 1 μM, 1.25 μM, 1.5 μM, 2.5 μM , 3 μM, 4 μM, 5 4 μM, 10 4 μM |
| Incubation Time: | 8 hours |
| Result: | Inhibited cell death in BAX-dependent manner. |