36062-04-1
36062-04-1 结构式
基本信息
四氢姜黄素
纳米四氢姜黄素
四氢-姜黄色素
水溶性四氢姜黄素
生物活性四氢姜黄素
四氢姜黄素(标准品)
纳米脂质体四氢姜黄素
纳米包裹辅酶四氢姜黄素
四氢姜黄素, 来源于姜黄
Nsc687845
HZIV 81-2
SabiWhite-
Aids110028
Aids-110028
BioaActive THC
NanoActive THC
TetrahydrocucuMin
etrahydrocurcumin
物理化学性质
制备方法
458-37-7
36062-04-1
以(1E,6E)-1,7-双(4-羟基-3-甲氧基苯基)庚-1,6-二烯-3,5-二酮为起始原料合成四氢姜黄素的一般步骤：将1g铂-铁-镍氢氧化物复合纳米粒子催化剂与100g姜黄素加入装有300ml乙醇的反应烧瓶中，于24℃室温条件下搅拌反应1小时。反应完成后，通过减压蒸馏除去溶剂，得到98g淡黄色粘性物质。将该物质溶解于400ml乙醇中，随后浓缩至150ml。将浓缩液置于冰箱中静置结晶，最终获得92.9g淡黄色固体产物，收率为92.9%。
参考文献：
[1] Patent: CN104496779, 2017, B. Location in patent: Paragraph 0014; 0015; 0016; 0017; 0018-0023
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 6, p. 495 - 497
[3] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 22, p. 6175 - 6181
[4] Bioscience, biotechnology, and biochemistry, 1995, vol. 59, # 9, p. 1609 - 1612
[5] Biochemical Pharmacology, 1996, vol. 52, # 4, p. 519 - 525
常见问题列表
四氢姜黄素为天然的姜黄根提取物中主要的美白活性成分，不仅具有最强的酪氨酸酶抑制活性，还具有极好的化学稳定性，而且外观为无味的白色粉末，从而克服了普通姜黄提取物化学不稳定易使皮肤染色的缺陷。普通的姜黄提取物为黄色，化学稳定性差，具有光敏性，在光照下，容易和皮肤发生化学反应而使皮肤染色。
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CYP2C9
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CYP3A4
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Human Endogenous Metabolite
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Autophagy
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Tetrahydrocurcumin (THC) has a number of attractive properties not shared with Curcumin that may make it superior. Tetrahydrocurcumin inhibited lipoxygenase as low as 1 μM. Tetrahydrocurcumin is tested for its ability to inhibit CYP2C9, CYP3A4, CYP1A2 and CYP2D6. Tetrahydrocurcumin yields dose-dependent inhibition of CYP2C9, and to a lesser extent, CYP3A4. Tetrahydrocurcumin exhibits maximum inhibition of CYP2C9 and CYP3A4 at 50 to 100 μM. Tetrahydrocurcumin does not show a consistent dose-response inhibition of CYP1A2 or CYP2D6 over the range of concentrations tested. In some cases, the percent inhibition exceeds 100%. The effect of Tetrahydrocurcumin on cancer cell viability is measured. Sup-T1 cells, T-cell lymphoblastic lymphoma cells, are treated with Tetrahydrocurcumin to determine its ability to induce growth inhibition using an MTS assay, and the corresponding IC50 values are in the mid-to-high micromolar range.
The serum Tetrahydrocurcumin (THC) concentration versus time curve shows that more than one absorption and distribution phase is present. Initially, a rapid absorption phase with an average Tmax of 6.8 μg/mL at 1 h is observed, followed by a short elimination phase. This is followed by two redistributions with two smaller Tetrahydrocurcumin maxima at 6 and 24 h. Both redistribution phases has similar maxima of about 1 μg/mL. The total amount of Tetrahydrocurcumin excrets unchanged in urine was up to 8 μg at 24 h.