3854-04-4
中文名称
Oxotremorine M
英文名称
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
CAS
3854-04-4
分子式
C11H19IN2O
分子量
322.186
MOL 文件
3854-04-4.mol
更新日期
2025/08/27 11:13:20
3854-04-4 结构式
基本信息
中文别名
碘化氧化震颤素M 英文别名
CPD3509Oxotremorine M (iodide)
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
物理化学性质
储存条件Desiccate at -20°C
溶解度DMSO : 125 mg/mL (387.97 mM; Need ultrasonic)
形态粉末
颜色Light yellow to yellow
水溶解性溶于水至100mM
Oxotremorine M价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-101372A | Oxotremorine M iodide | 3854-04-4 | 5 mg | 312元 |
| 2025/05/22 | HY-101372A | Oxotremorine M Oxotremorine M iodide | 3854-04-4 | 10mg | 500元 |
| 2025/05/22 | HY-101372A | Oxotremorine M Oxotremorine M iodide | 3854-04-4 | 10mM * 1mLin DMSO | 550元 |
常见问题列表
生物活性
Oxotremorine M iodide 是一种有效的，非选择性毒蕈碱型乙酰胆碱受体 (mAChR) 激动剂。Oxotremorine M iodide 通过毒蕈碱受体依赖和独立机制增强 NMDA 受体。体外研究
Oxotremorine M iodide (0.1, 0.3, 1, 3, 10, 30 μM) inhibits KCNQ2/3 currents in the concentration-dependence.
Oxotremorine M iodide elicits a robust phosphoinositide response characterized with an EC
50
of 0.22 μM. Oxotremorine M iodide has EC
50
s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively.
体内研究
Oxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g.