440122-66-7
440122-66-7 结构式
基本信息
7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
WAY200070
WAY 200070
7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
物理化学性质
制备方法
67-56-1
440123-20-6
440122-66-7
步骤e）7-溴-2-(4-羟基苯基)-1,3-苯并恶唑-5-醇的合成路线a）操作如下：在-70℃条件下，将三溴化硼（1M，89.9mL，89.8mmol）逐滴加入到7-溴-5-甲氧基-2-(4-甲氧基苯基)-1,3-苯并恶唑（10.0g，29.94mmol）与二氯甲烷（50mL）的悬浮液中。反应混合物逐渐升温至室温，期间悬浮液转变为黑色溶液。室温下持续搅拌反应混合物2天后，将其缓慢倒入预冷（0℃）的乙醚（1000mL）中。随后，在20分钟内缓慢加入甲醇（200mL）至上述混合物中。将混合液倒入水（1.5L）中，分离有机层，用水洗涤三次，并用无水硫酸镁干燥。通过蒸发浓缩后，从丙酮/乙醚/己烷混合溶剂中结晶，得到灰白色固体产物（8.4g，收率92%，熔点298-299℃）；质谱分析显示m/e 306（M + H）+。
参考文献：
[1] Patent: US2003/199562, 2003, A1
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-101271 | 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 WAY-200070 | 440122-66-7 | 10mM * 1mLin DMSO | 350元 |
| 2025/05/22 | HY-101271 | 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 WAY-200070 | 440122-66-7 | 5mg | 520元 |
| 2025/05/22 | HY-101271 | 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 WAY-200070 | 440122-66-7 | 10mg | 830元 |
常见问题列表
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)
Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.