76-74-4
中文名称
戊巴比妥
英文名称
Pentobarbital
CAS
76-74-4
EINECS 编号
200-983-8
分子式
C11H18N2O3
MDL 编号
MFCD00057561
分子量
226.27
MOL 文件
76-74-4.mol
76-74-4 结构式
基本信息
中文别名
5-乙基-5-(1-甲基丁基)-2,4,6-(1H,3H,5H)-嘧啶三酮5-乙基-5-(1-甲基丁基)巴比妥酸
戊巴比妥
英文别名
5-ETHYL-5-[1-METHYLBUTYL]-2,4,6-TRIOXOHEXAHYDROPYRIMIDINE5-ethyl-5-(1-methylbutyl)barbituric acid
5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione
PENTOBARBITAL
pentobarbitone
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-
5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
5-Ethyl-5-(1-methylbutyl)barbituric acidcid
5-ethyl-5-(1-methylbutyl)-barbituricaci
5-Ethyl-5-(1-methylbutyl)malonylurea
5-Ethyl-5-(sec-pentyl)barbituric acid
5-ethyl-5-(sec-pentyl)barbituricacid
6(1h,3h,5h)-pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-4
Barbituric acid, 5-ethyl-5-(1-methylbutyl)-
barbituricacid,5-ethyl-5-(2-pentyl)
component of Emesert
Dorsital
Ethaminal
Ethyl-propylmethylcarbinylbarbituric acid
ethyl-propylmethylcarbinylbarbituricacid
所属类别
原料药：其它神经系统用药物理化学性质
熔点129.5°C
沸点367.89°C (rough estimate)
密度1.1376 (rough estimate)
折射率1.4620 (estimate)
闪点9℃
储存条件2-8°C
溶解度Very slightly soluble in water, freely soluble in ethanol. It forms water-soluble compounds with alkali hydroxides and carbonates and with ammonia.
酸度系数(pKa)pK1:8.11(0) (25°C)
形态A neat solid
水溶解性679 mg/L
Henry's Law Constant1.2×107 mol/(m3Pa) at 25℃, HSDB (2015)
NIST化学物质信息Pentobarbital(76-74-4)
EPA化学物质信息Pentobarbital (76-74-4)
安全数据
警示词危险
危险性描述H301-H336-H361d
危险品标志T,F
危险品运输编号UN 2811 6.1/PG 3
WGK Germany3
RTECS号CQ5775000
REACH 注册登记Active
危险等级6.1(b)
包装类别III
海关编码2933530000
毒性A barbiturate that
causes CNS depression, apparently due to a facilitation of
GABA-ergic inhibition. It appears that the site of action of pentobarbital may be the macromolecular complex made up of a
GABA receptor, chloride channel, benzodiazepine-binding site,
and picrotoxin-binding site. Barbiturates have been shown to
compete for dihydropicrotoxinin-binding sites. In clinical use,
barbiturates such as pentobarbital have been largely replaced
as sedative-hypnotics by the much safer benzodiazepines. The
sedative-hypnotic properties of barbiturates may lead to abuse, as
tolerance and dependence are known to occur. In animals, pentobarbital is routinely used for its anesthetic and anticonvulsant
properties, as well as for euthanasia. Pentobarbital, like other
barbiturates, can induce the metabolism of other compounds by
altering cytochrome P450 activity. The oral LD50 in rats is
118 mg/kg.