865305-30-2
中文名称
5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺
英文名称
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
CAS
865305-30-2
分子式
C14H17IN4O2
分子量
400.21
MOL 文件
865305-30-2.mol
更新日期
2025/05/09 15:07:09
865305-30-2 结构式
基本信息
中文别名
5-(5-碘-2-异丙基-4-甲氧基苯氧基)嘧啶-2,4-二胺5-[5-碘-4-甲氧基-2-(1-甲基乙基)苯氧基]-2,4-嘧啶二胺
英文别名
Ro 4AF 353
CS-2469
CHEMBL526307
AF-353 (Ro-4)
CHEMBL526307
AF 353
AF353
5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine
5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride Ro 4 hydrochloride
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点510.2±60.0 °C(Predicted)
密度1.619±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 32 mg/mL (79.96 mM)
酸度系数(pKa)6.89±0.10(Predicted)
形态Solid
颜色Light brown to brown
应用领域
用途1
一种p2x3受体拮抗剂。AF353 is a P2X3 receptor antagonist. Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system.