865783-99-9
中文名称
BRICICLIB
英文名称
Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)
CAS
865783-99-9
分子式
C19H23O10PS
分子量
474.42
MOL 文件
865783-99-9.mol
更新日期
2025/05/22 09:46:38
865783-99-9 结构式
基本信息
中文别名
布瑞西利布瑞西利, >98%
化合物BRICICLIB
BRICICLIB (SYNONYMS: ON 014185)
英文别名
CS-2580ON-014185
Briciclib, >98%
Briciclib,ON-014185
Briciclib(ON 013105,ON 014185)
ON013105
ON014185
ON-013105
ON-014185
(E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate
2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate
Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)
所属类别
生物化工：激动剂抑制剂
常见问题列表
生物活性
Briciclib (ON-014185)是ON-013100的水溶性衍生物。ON-013100是一种可与eIF4E结合并抑制其活性的小分子化合物。靶点
eIF4E
体外研究
Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI 50 s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.