879127-16-9
中文名称
AURORA KINASE INHIBITOR III
英文名称
Aurora Kinase Inhibitor III
CAS
879127-16-9
分子式
C21H18F3N5O
分子量
413.4
MOL 文件
879127-16-9.mol
更新日期
2026/01/19 16:10:10
879127-16-9 结构式
基本信息
中文别名
极光激酶抑制剂III化合物AURORA KINASE INHIBITOR III
化合物AURORA KINASE INHIBITOR III,10 MM DMSO 溶液
N-(3-((4-((3-(三氟甲基)苯基)氨基)嘧啶-2-基)氨基)苯基)环丙烷甲酰胺
英文别名
AKI-7169Aurora Kinase Inhibitor 3
Aurora Kinase Inhibitor III
AKI-7169(Aurora Kinase Inhibitor III)
Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem
N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide
Cyclopropanecarboxamide, N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide >=98% (HPLC), solid
所属类别
生物化工：抑制剂物理化学性质
密度1.456±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度H2O：<2毫克/毫升
酸度系数(pKa)14.51±0.70(Predicted)
形态白色固体
颜色白色
水溶解性H2O: <2mg/mL
DMSO: >7mg/mL
DMSO: >7mg/mL
InChI1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29)
InChIKeyRDTDWGQDFJPTPD-UHFFFAOYSA-N
SMILESFC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1
AURORA KINASE INHIBITOR III价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/12/22 | HY-112373 | AURORA KINASE INHIBITOR III Aurora kinase inhibitor-3 | 879127-16-9 | 1mg | 600元 |
| 2025/12/22 | HY-112373 | AURORA KINASE INHIBITOR III Aurora kinase inhibitor-3 | 879127-16-9 | 5mg | 1500元 |
| 2025/12/22 | HY-112373 | Aurora kinase inhibitor-3 | 879127-16-9 | 10 mg | 2400元 |
常见问题列表
生物活性
Aurora kinase inhibitor III是有效的Aurora A kinase抑制剂，IC50为42 nM。它对BMX, BTK, IGF-1R, c-Src, TRKB, SYK和EGFR分别为386, 3550, 591, 1980, 2510, 887和>10,000 nM。靶点
| Target | Value |
|
Aurora A
(Cell-free assay) | 42 nM |
|
BMX
(Cell-free assay) | 386 nM |
|
IGF-1R
(Cell-free assay) | 591 nM |
|
SYK
(Cell-free assay) | 887 nM |
|
c-Src
(Cell-free assay) | 1980 nM |