914291-61-5
914291-61-5 结构式
基本信息
中文别名
化合物 T12567 英文别名
PS3724243-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[(cyclohexylmethyl)amino]carbonyl]butyl]-2-(1,4-dioxo-4-phenylbutyl)-1,2,3,4-tetrahydro-, (3S)-
物理化学性质
密度1.29±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)13.47±0.20(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
PS372424，CXCL10 的三个氨基酸片段，是一种特异的人 CXCR3 激动剂，具有抗炎活性。在关节炎炎症模型中，PS372424 可抑制 T 细胞迁移。靶点
|
Human CXCR3
|
体外研究
PS372424 (100 ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5 min of stimulation.
PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3
+
T cells not in CXCR3
-
T cells.
PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC
50
of 42±21 nM.
Western Blot Analysis
| Cell Line: | CXCR3 + T cells and CXCR3 - T cells |
| Concentration: | 10, 50, 100, or 200 nM |
| Incubation Time: | 30 minutes |
| Result: | Caused a concentration-dependent phosphorylation of CCR5 on CXCR3 + T cells. Did not result in phosphorylation of CCR5 on CXCR3 - T cells. |