924636-93-1

英文名称 Benzamide, N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)-

CAS 924636-93-1

分子式 C22H17F3N2O

分子量 382.38

MOL 文件 924636-93-1.mol

924636-93-1 结构式

基本信息应用领域

基本信息

英文别名

Benzamide, N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)-

应用领域

用途一

AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional relevance of this observation deserves to be investigated in vivo.