980-71-2
中文名称
马来酸溴苯那敏
英文名称
Brompheniramine hydrogen maleate
CAS
980-71-2
EINECS 编号
213-562-9
分子式
C20H23BrN2O4
MDL 编号
MFCD00057367
分子量
435.31
MOL 文件
980-71-2.mol
更新日期
2025/05/06 14:33:21
980-71-2 结构式
基本信息
中文别名
N,N-二甲基-gamma-(4-溴苯基)-2-吡啶丙胺顺丁烯二酸盐马来酸溴苯那敏
溴苯那敏
英文别名
1-(n,n-dimethylamino)-3-(p-bromophenyl)-3-(alpha-pyridyl)propane maleate1-p-bromophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
BROMOPHENIRAMINE MALEATE
brompheniramine hydrogen maleate
BROMPHENIRAMINE MALEATE
(+/-)-BROMPHENIRAMINE MALEATE SALT
BROMPHENIRAMINE MALEATE SALT
2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate(1:1)
2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)
dimegan
dimetane
dimetanemaleate
dimotane
g-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate
gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate
gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-butenedioate
ilvinmaleate
parabromdylaminemaleate
parabromodylaminemaleate
γ-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate
所属类别
原料药：抗组胺药物理化学性质
熔点134-135°C
闪点9℃
储存条件Inert atmosphere,Room Temperature
溶解度Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
形态neat
颜色白色至灰白色
最大波长(λmax)261nm(lit.)
Merck14,1443
稳定性吸湿性
InChIKeySRGKFVAASLQVBO-BTJKTKAUSA-N
LogP3.565 (est)
980-71-2(安全特性,毒性,储运)
储运特性
库房通风低温干燥; 与食品原料类分开存放毒性分级
高毒急性毒性
口服-大鼠 LD50: 318 毫克/公斤; 腹腔-大鼠 LD50: 76 毫克/公斤可燃性危险特性
热分解排出有毒氮氧化物和溴化物,氯化氢烟雾类别
有毒物质灭火剂
水,干粉、干砂、二氧化碳、泡沫、1211灭火剂马来酸溴苯那敏价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-B0480 | 马来酸溴苯那敏 Brompheniramine maleate | 980-71-2 | 50mg | 714元 |
| 2025/02/08 | HY-B0480 | 马来酸溴苯那敏 Brompheniramine maleate | 980-71-2 | 10mM * 1mLin DMSO | 785元 |
| 2025/02/08 | HY-B0480 | 马来酸溴苯那敏 Brompheniramine maleate | 980-71-2 | 100mg | 1000元 |
常见问题列表
生物活性
Brompheniramine hydrogen maleate是一种组胺H1受体拮抗剂。靶点
| Target | Value |
| Histamine H1 receptor |
体外研究
In in vitro experiments, Brompheniramine blocks muscarinic cholinergic receptors in human chinese hamster ovary (CHO) cells, sodium and calcium channels in CHO cells, as well as potassium channels in human embryonic kidney 293 (HEK-293) cells. Brompheniramine suppresses the transfected Nav 1.5 channels from myocytes.
体内研究
Brompheniramine as an antihistamine blocks sodium channels. Brompheniramine (3.0, 1.5, 1.1, 0.6, and 0.3 μmol) treatment shows cutaneous analgesic effect with an ED 50 value of 0.89 in a rat model of infiltration anesthesia. Subcutaneous Brompheniramine induces dose-relatedly analgesic effects, and Brompheniramine induces prolonged analgesic duration.