(S)-1-Boc-3-氨基哌啶
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- CAS号:
- 625471-18-3
- 英文名:
- (S)-3-Amino-1-N-Boc-piperidine
- 英文别名:
- (S)-1-BOC-3-AMINOPIPERIDINE;(S)-TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE;S-1-BOC-3-aminopiperdine;(S)-1-BOC-3-PIPERIDINAMINE;(S)-N-BOC-3-AMINOPIPERIDINE;(S)-1-BOC-3-AMNIOPIPERIDINE;(S)-3-AMINO-1-BOC-PIPERIDINE;(S)-3-AMino-1-Boc-piperid...;(S)-3-AMINO-N-TBOC-PIPERIDINE;（S）-3-Amino-1-N-Boc-pieridine
- 中文名:
- (S)-1-Boc-3-氨基哌啶
- 中文别名:
- (S)-1-B℃-3-氨基哌啶;(S)-1-Boc-3-氨基哌啶;(S)-1-BOC-3-胺基哌啶;(S)-N-BOC-3-氨基哌啶;(S)-1-叔丁氧羰基-3-氨哌啶;(S)-3-氨基-1-哌啶羧酸叔丁酯;(S)-3-氨基-N-叔丁氧羰基哌啶;(S)-1-叔丁氧羰基-3-氨基哌啶;(R)-3-氨基-N-叔丁氧羰基哌啶;(S)-3-氨基-1-叔丁氧羰基哌啶
- CBNumber:
- CB0258317
- 分子式:
- C10H20N2O2
- 分子量:
- 200.28
- MOL File:
- 625471-18-3.mol
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(S)-1-Boc-3-氨基哌啶化学性质
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比旋光度:
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-28.5 º (c=1, DMF)
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沸点:
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277.3±33.0 °C(Predicted)
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密度:
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1.02
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折射率:
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1.4690-1.4730
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闪点:
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122℃
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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Soluble in dimethylsulfoxide.
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酸度系数(pKa):
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10.35±0.20(Predicted)
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形态:
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Gum or Semi-Solid
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颜色:
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Colorless to yellow
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旋光度 (Optical Rotation):
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[α]/D +32.0±3°, c = 1 in DMF
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敏感性:
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Air Sensitive
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InChI:
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InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m0/s1
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InChIKey:
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AKQXKEBCONUWCL-QMMMGPOBSA-N
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SMILES:
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N1(C(OC(C)(C)C)=O)CCC[C@H](N)C1
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CAS 数据库:
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625471-18-3(CAS DataBase Reference)
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(S)-1-Boc-3-氨基哌啶性质、用途与生产工艺
(S)-1-Boc-3-氨基哌啶用作通用试剂、医药中间体等。
生产方法
以化合物（CAS:1271240-70-0）为原料合成(S)-1-Boc-3-氨基哌啶的一般步骤：将叠氮基衍生物42a（6.77 g，29.9 mmol）与Pd/C催化剂（150 mg）在乙醇（200 mL）中混合，于大气压下进行氢化反应过夜。反应完成后，通过硅藻土过滤去除催化剂，随后蒸发溶剂。得到产物43a，为无色液体，无需进一步纯化，产率为90%（5.39 g，26.9 mmol）。产物的1H NMR、13C NMR和IR光谱数据与文献报道的30一致。高分辨质谱（HRMS，ESI）分析显示，C10H21O2N2（[M + H]+）的计算值为201.1598，实测值为201.1597；比旋光度[α]D20为+26.0（c 0.308，EtOH）。
参考文献：
[1] Tetrahedron, 2011, vol. 67, # 7, p. 1485 - 1500
[2] Patent: WO2005/305, 2005, A1. Location in patent: Page 60
[3] Patent: WO2005/20976, 2005, A2. Location in patent: Page/Page column 239
[4] Patent: WO2005/60949, 2005, A2. Location in patent: Page/Page column 238
(S)-1-Boc-3-氨基哌啶
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2026/07/06 | H30538 | (S)-(+)-1-Boc-3-氨基哌啶, 97%
(S)-(+)-3-Amino-1-Boc-piperidine, 97% | 625471-18-3 | 1g | 746元 |
| 2026/07/06 | 43749 | S-1-BOC-3-氨基哌啶
(S)-(+)-3-Amino-1-BOC-piperidine, 95%, Thermo Scientific Chemicals | 625471-18-3 | 5g | 8602元 |
625471-18-3, (S)-1-Boc-3-氨基哌啶 相关搜索:
- Piperidines
- Pyrans, Piperidines & Piperazines
- AMINOACID
- Piperidine Series
- Piperidine
- Pyrans, Piperidines &Piperazines
- Amines
- pharmacetical
- 化工中间体
- 医用原料
- 化工原料及中间体
- 高端化学
- 化学试剂
- 杂质对照品
- 医药中间体
- 通用试剂
- 杂环砌块
- 中间体
- 哌啶
- 哌啶系列
- 哌啶类
- 625471-18-7
- 625471-18-5
- 625471-18-6
- 625471-18-4
- 625471-18-8
- (S)-1-叔丁氧羰基-3-氨基呱啶
- 叔-丁基 (3S)-3-氨基哌啶-1-甲酸基酯
- (S)-3-氨基哌啶-1-羧酸叔丁酯
- (S)-N-BOC-3-氨基哌啶
- (S)-3-氨基-1-叔丁氧羰基哌啶
- (R)-3-氨基-N-叔丁氧羰基哌啶
- (S)-(+)-1-BOC-3-氨基哌啶,97%
- (S)-叔丁基3-氨基哌啶-1-羧酸酯
- (S)-1-BOC-3-氨基哌啶 1G
- S-1-BOC-3-氨基哌啶(CAS号:625471-18-3)
- (S)-3-氨基-1-哌啶羧酸叔丁酯
- (S)-1-叔丁氧羰基-3-氨哌啶
- (S)-(+)-3-氨基-1-BOC-哌啶
- (S)-1-BOC-3-胺基哌啶
- (S)-3-氨基-N-叔丁氧羰基哌啶
- (S)-1-B℃-3-氨基哌啶
- (S)-3-氨基-1-N-BOC-哌啶
- (S)-1-N-Boc-3-氨基-哌啶
- (S)-1-Boc-3-氨基哌啶
- (S)-1-叔丁氧羰基-3-氨基哌啶
- 625471-18-3
- (S)-TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE
- (S)-1-BOC-3-AMINOPIPERIDINE
- S-3-amino-1-N-Boc-piperidine 98%
- (S)-(+)-3-Amino-1-Boc-piperidine
- （S）-3-Amino-1-N-Boc-pieridine
- (S)-tert-Butyl 3-amino-piperidin-1-carboxylate
- tert-Butyl(S)-3-aminopiperidine-1-carboxylate
- (S)-3-Amino-1-N-Boc-piperidine USP/EP/BP
- (S)-tert-Butyl 3-Amino-1-piperidinecarboxylate
- (S)-3-aminopiperidine-1-carboxylate
- (S)-3-Amino-1-tert-butoxycarbonylpiperidine >