网站主页 >> CAS数据库列表 >> 2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺
2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺
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- CAS号:
- 474960-44-6
- 英文名:
- 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide
- 英文别名:
- CS-1139;SB 657510;SB 657510,SB657510;SB-657510, 10 mM in DMSO;(R)-2-Bromo-N-(4-chloro-3-((1-methylpyrrolidin-3-yl)oxy)phenyl)-4,5-dimethoxybenzenesulfonamide;2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide;2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxy-phenyl]-4,5-dimethoxy-benzenesulfonamide;BenzenesulfonaMide, 2-broMo-N-[4-chloro-3-[[(3R)-1-Methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-diMethoxy-
- 中文名:
- 2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺
- 中文别名:
- 化合物 T12848;化合物 SB-657510;SB 657510,尿紧张素II(UT)受体拮抗剂;化合物SB-657510,10 MM DMSO 溶液;(R)-2-溴-N-(4-氯-3-((1-甲基吡咯烷-3-基)氧基)苯基)-4,5-二甲氧基苯磺酰胺;2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷]氧基]苯基]-4,5-二甲氧基苯磺酰胺;2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺
- CBNumber:
- CB12518915
- 分子式:
- C19H22BrClN2O5S
- 分子量:
- 505.81
- MOL File:
- 474960-44-6.mol
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2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺化学性质
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沸点:
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585.0±60.0 °C(Predicted)
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密度:
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1.512±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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DMSO: ≥30mg/mL
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形态:
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powder
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酸度系数(pKa):
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6.60±0.10(Predicted)
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颜色:
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white to off-white
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2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺性质、用途与生产工艺
SB-657510 是选择性的 urotensin II (UII) receptor (UT) 拮抗剂。 对于人，猴，猫，大鼠和小鼠的受体的 Ki 值分别为 61、17、30、65 和 56 nM。SB-657510 通过抑制 UII 诱导的人类血管内皮细胞中炎性介质，如粘附分子，细胞因子和组织因子上调发挥抗炎作用。
SB-657510 dramatically blocks the UII-induced increase in adhesion between U937 and EA.hy926 cell. SB-657510 (1 μM; 0.5-8 hours) blocks the expression of tissue factor induced by UII in endothelial cells.
SB-706375 (1-10000 nM) inhibits [Ca
2+
]
i
mobilization elicited by 10 nM hU-II with an IC
50
of 180 nM.
Western Blot Analysis
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Cell Line:
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EA.hy926 cells (UII-induced)
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Concentration:
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1 μM
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Incubation Time:
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0.5, 1, 2, 4, 8 hours
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Result:
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Remarkably decreased the UII-induced protein expression of tissue factor.
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SB-657510 inhibits the progression of high-fat diet induced atherosclerosis and diabetes-associated atherosclerosis.
Levels of phosphorylated ERK are significantly attenuated in the aorta of SB-657510-treated (30 mg/kg/day) diabetic mice (Male Apoe KO mice).
2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-10656 | 2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺
SB-657510 | 474960-44-6 | 1mg | 589元 |
| 2025/05/22 | HY-10656 | 2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺
SB-657510 | 474960-44-6 | 5mg | 1463元 |
2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺
生产厂家
474960-44-6, 2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺 相关搜索:
- 抑制剂
- 药靶配体
- C19H22BrCIN2O5S
- C19H22BrClN2O5S
- 化合物SB-657510,10 MM DMSO 溶液
- 化合物 SB-657510
- (R)-2-溴-N-(4-氯-3-((1-甲基吡咯烷-3-基)氧基)苯基)-4,5-二甲氧基苯磺酰胺
- SB 657510,尿紧张素II(UT)受体拮抗剂
- 化合物 T12848
- 2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷]氧基]苯基]-4,5-二甲氧基苯磺酰胺
- 2-溴-N-[4-氯-3-[[(3R)-1-甲基-3-吡咯烷基]氧基]苯基]-4,5-二甲氧基-苯磺酰胺
- 474960-44-6
- SB-657510, 10 mM in DMSO
- (R)-2-Bromo-N-(4-chloro-3-((1-methylpyrrolidin-3-yl)oxy)phenyl)-4,5-dimethoxybenzenesulfonamide
- SB 657510,SB657510
- 2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxy-phenyl]-4,5-dimethoxy-benzenesulfonamide
- BenzenesulfonaMide, 2-broMo-N-[4-chloro-3-[[(3R)-1-Methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-diMethoxy-
- SB 657510
- CS-1139
- 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide