苦参醇
|
|
|
- CAS号:
- 855746-98-4
- 英文名:
- Kurarinol
- 英文别名:
- 4'',5''-Dihydro-5''-hydroxysophoraflavanone G 5-methyl ether;KurarinolQ: What is
Kurarinol Q: What is the CAS Number of
Kurarinol;2-(2,4-dihydroxy-phenyl)-7-hydroxy-8-[2-(3-hydroxy-3-methyl-butyl)-3-methyl-but-3-enyl]-5-methoxy-chroman-4-one;(2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2S)-
- 中文名:
- 苦参醇
- 中文别名:
- CBNumber:
- CB13037363
- 分子式:
- C26H32O7
- 分子量:
- 456.53
- MOL File:
- 855746-98-4.mol
|
|
|
苦参醇化学性质
-
熔点:
-
166-169 °C
-
|
-
沸点:
-
683.8±55.0 °C(Predicted)
-
|
-
密度:
-
1.250±0.06 g/cm3(Predicted)
-
|
-
溶解度:
-
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
-
|
-
形态:
-
Powder
-
|
-
酸度系数(pKa):
-
7.54±0.40(Predicted)
-
|
苦参醇性质、用途与生产工艺
Kurarinol 是一种黄烷酮，在 Sophora flavescens 根中被发现。Kurarinol 是一种竞争性的酪氨酸酶 (tyrosinase) 抑制剂，对蘑菇型酪氨酸酶作用的 IC50 为 0.1 μM 。
IC50: 0.1 μM (mushroom tyrosinase)
Kurarinol manifests relatively low cytotoxic activity (EC
50
>30 μM).
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism.
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3).
Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats.
|
Animal Model:
|
Male Sprague-Dawley rats (120-130g), hypercholesterolemic models
|
|
Dosage:
|
20 mg/kg
|
|
Administration:
|
Oral administration, daily, for 3 days
|
|
Result:
|
Decreased serum TC, TG, and LDL-C levels.
|
苦参醇
上下游产品信息
上游原料
下游产品
855746-98-4, 苦参醇 相关搜索:
- 标准品
- 标准品 -中药标准品
- 对照品
- 中药对照品
- 855746-98-4
- KurarinolQ: What is
Kurarinol Q: What is the CAS Number of
Kurarinol
- 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2S)-
- 2-(2,4-dihydroxy-phenyl)-7-hydroxy-8-[2-(3-hydroxy-3-methyl-butyl)-3-methyl-but-3-enyl]-5-methoxy-chroman-4-one
- 4'',5''-Dihydro-5''-hydroxysophoraflavanone G 5-methyl ether
- (2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one