苦参醇
| 中文名称 | 苦参醇 |
|---|---|
| 中文同义词 | |
| 英文名称 | Kurarinol |
| 英文同义词 | (2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one;4'',5''-Dihydro-5''-hydroxysophoraflavanone G 5-methyl ether;2-(2,4-dihydroxy-phenyl)-7-hydroxy-8-[2-(3-hydroxy-3-methyl-butyl)-3-methyl-but-3-enyl]-5-methoxy-chroman-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2S)-;KurarinolQ: What is Kurarinol Q: What is the CAS Number of Kurarinol |
| CAS号 | 855746-98-4 |
| 分子式 | C26H32O7 |
| 分子量 | 456.53 |
| EINECS号 | |
| 相关类别 | 中药对照品;对照品;标准品 -中药标准品;标准品 |
| Mol文件 | 855746-98-4.mol |
| 结构式 |  |
苦参醇 性质
| 熔点 | 166-169 °C |
|---|---|
| 沸点 | 683.8±55.0 °C(Predicted) |
| 密度 | 1.250±0.06 g/cm3(Predicted) |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 7.54±0.40(Predicted) |
Kurarinol 是一种黄烷酮，在 Sophora flavescens 根中被发现。Kurarinol 是一种竞争性的酪氨酸酶 (tyrosinase) 抑制剂，对蘑菇型酪氨酸酶作用的 IC50 为 0.1 μM 。
IC50: 0.1 μM (mushroom tyrosinase)
Kurarinol manifests relatively low cytotoxic activity (EC
50
>30 μM).
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism.
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3).
Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats.
| Animal Model: | Male Sprague-Dawley rats (120-130g), hypercholesterolemic models |
| Dosage: | 20 mg/kg |
| Administration: | Oral administration, daily, for 3 days |
| Result: | Decreased serum TC, TG, and LDL-C levels. |