1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶

1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶性质、用途与生产工艺

用途 

生产方法 

2107-69-9

22065-85-6

120014-07-5

以5,6-二甲氧基茚酮（60.0 g）和1-苄基-4-哌啶甲醛（70.5 g）为原料，在氢氧化钾（13.6 g）和苄基三乙基氯化铵（3.56 g）的存在下，悬浮于甲苯（380 mL）中。随后，在室温下向悬浮液中加入水（42 mL）。通入氮气鼓泡30分钟后，将混合物加热至回流温度。保持回流搅拌8小时后，加入水（380 mL），并通过蒸馏去除甲苯。反应混合物冷却后，过滤分离得到目标产物1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶晶体，产量为140 g（定量产率；干燥失重：13.3%，实际得到121 g）。

参考文献：

[1] Patent: US2009/253746, 2009, A1. Location in patent: Page/Page column 3

[2] Patent: EP1911745, 2008, A1. Location in patent: Page/Page column 11-12

[3] Patent: EP1911745, 2008, A1. Location in patent: Page/Page column 10

[4] Patent: EP1911745, 2008, A1. Location in patent: Page/Page column 14

[5] Organic Process Research and Development, 2008, vol. 12, # 4, p. 731 - 735

1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶 上下游产品信息

上游原料

下游产品

1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶 生产厂家

120014-07-5, 1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶 相关搜索:

• Pharmaceuticals
• Intermediates & Fine Chemicals
• Intermediates
• Heterocycles
• Aromatics
• 杂质对照品
• 标准品
• C24H27NO3
• 脱氢碘苄嗪
• RSYY(阿哌沙班)-42
• 2-((1-苯甲基哌啶-4-基)亚甲基)-5,6-二甲氧基-2,3-二氢-1H-茚-1-酮
• 1-BENZYL-4-[(5,6-DIMETHOXY-1-OXOINDAN-2-YLIDENE)METHYL]PIPERIDINE[干冰运输]
• 脱氢多奈哌齐
• 多奈哌齐美国药典相关化合物 A
• 多奈哌齐相关化合物
• 多奈哌齐标准品3-Z
• 1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶
• 多奈哌齐相关化合物(E/Z混合物)
• 多奈哌齐标准品013
• 多奈哌齐杂质;1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶
• 2-((1-苄基哌啶-4-基)亚甲基)-5,6-二甲氧基-2,3-二氢-1H-茚-1-酮
• 1-苄基-4-[(5,6-二甲氧基-1-茚酮)-2-次甲基]-哌啶
• 盐酸多奈哌齐USP相关物质A
• 1 - 苄基-4 - [(5,6 - 二甲氧基-1-氧茚2 - 亚基)甲基]哌啶
• 多奈哌齐相关物质
• 120014-07-5
• Donepezil imp B
• (Z)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
• (E)-1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
• 2-[(1-Benzylpiperidin-4-yl)methylene]-2,3-dihydro-5,6-dimethoxyinden-1-one
• Donepezil Dehydro Impurity (E/Z mixture)
• 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperi...
• 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine DISCONTINUED. Please see D229775
• 2-[(1-Benzylpiperidin-4-yl)methylen
• Donepezil Impurity 17
• Donepezil-013-Z
• Donepezil Impurity O
• 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
• 2-[(1-benzyl-4-piperidyl)methyleen]-5,6-dimethoxyindan-1-on
• 1-benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
• Donepezil related compound
• Donepezil impurity 16/1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
• Donepezil-013
• Dehydro Donepezil
• (E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
• 1H-Inden-1-one, 2,3-dihydro- 5,6-diMethoxy-2-[[1-( phenylMethyl)-4-piperidinyl] Methylene]-
• Donepezil related coMpound (E/Z Mixture)
• 2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one
• 1-Benzyl-4-[(1,3-dihydro-5,6-dimethoxy-1-oxo-2H-inden-2-ylidene)methyl]piperidine
• Donepezil USP RC A
• Dehydro Donepezi
• 1-Benzyl-4-(5,6-diMethoxy-1-oxoindan-2-ylindeneMet
• 1-Benzyl-4-[(5,6-diMethoxy-1-oxoindan-2-ylidene)Methyl]piperidine (Donepezil IMpurity)
• 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydroinden-1-one
• Dehydro Donepezil (Donepezil Impurity)
• 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one
• 2-(1-Benzylpiperidin-4-ylmethylidene)-5,6-dimethoxyindan-1-one
• 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine